Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, R.O.C.
Mol Pharm. 2020 Sep 8;17(9):3461-3476. doi: 10.1021/acs.molpharmaceut.0c00504. Epub 2020 Aug 19.
Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration. Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications. In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked -maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers. With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility. These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.
由于壳聚糖 (CS) 的细胞亲和性和聚乙烯氧化物 (PEO) 的亲水性，CS/PEO 复合纳米纤维网 (NFM) 已被广泛用作皮肤组织再生的伤口愈合敷料。然而，NFM 系统存在许多固有缺陷，例如使用有毒的纺丝溶剂和交联剂、适度的水恢复能力以及缺乏触发释放功能，这极大地阻碍了它们在生物医学中的应用。为了提高其促进细胞生长和防止细菌感染的性能，通过无酸电纺工艺和 UV 辐照交联处理，而不使用含醛交联剂，开发了高溶胀交联 -马来酰基功能化壳聚糖 (MCS)/PEO NFM 作为下一代 CS/PEO NFM 系统。通过在交联中同时引入氧化乙烯链和二硫键，这种新的 NFM 系统显示出增强的溶胀能力、抗菌能力、触发抗生素释放和高生物相容性。这些生物医学优点使得新的 NFM 系统可用于组织支架，特别是用于功能性伤口愈合敷料。
