Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330031, PR China.
Epigenomics. 2020 Aug;12(15):1333-1348. doi: 10.2217/epi-2020-0217. Epub 2020 Aug 13.
To develop an oxidative phosphorylation (OXPHOS)-related gene signature of lung adenocarcinoma (LUAD). We split The Cancer Genome Atlas LUAD cohort into a training set and a test set; we used the least absolute shrinkage and selection operator Cox method to structure the OXPHOS-related prognostic signature in the training set and verified in the test set and GSE30219 dataset. Meanwhile, the diagnostic model was constructed using the logistic Cox method. The signature consisted of seven genes (, , , , , , and ). LUAD patients were divided into high- and low-risk groups, demonstrating good diagnostic and prognostic capabilities. We developed the first-ever OXPHOS-related signature with both prognostic predictive power and diagnostic efficacy.
构建肺腺癌（LUAD）的氧化磷酸化（OXPHOS）相关基因特征。我们将癌症基因组图谱 LUAD 队列分为训练集和测试集；我们使用最小绝对值收缩和选择算子 Cox 方法在训练集中构建 OXPHOS 相关预后特征，并在测试集和 GSE30219 数据集中进行验证。同时，使用逻辑 Cox 方法构建诊断模型。该特征由 7 个基因（，，，，，，和）组成。LUAD 患者被分为高风险组和低风险组，表现出良好的诊断和预后能力。我们首次开发了具有预后预测能力和诊断疗效的 OXPHOS 相关特征。
