Department for Obesity, Metabolic and Reproductive Disorders, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Dr Subotica 13, 11000 Belgrade, Serbia.
Curr Pharm Des. 2020;26(43):5584-5590. doi: 10.2174/1381612826666200813134328.
A growing number of patients with adrenal incidentalomas and subclinical Cushing's syndrome (SCS) led to an increasing number of different guidelines, and diagnostic and treatment recommendations. Excess cortisol secretion in patients with SCS is associated with several comorbidities, such as hypertension, dyslipidemia, type 2 diabetes mellitus, and obesity, which in the long-term increase mortality of these patients. Subtle cortisol secretion affects bone health, quality of life and causes depression, but due to the unapparent clinical features, patients with SCS are often at risk between over and under treatment. This narrative review aimed to summarize the latest recommendations on the approach to the patient with subclinical Cushing's syndrome.
越来越多的肾上腺意外瘤和亚临床库欣综合征 (SCS) 患者导致了越来越多不同的指南和诊断及治疗建议。SCS 患者皮质醇分泌过多与多种合并症相关，如高血压、血脂异常、2 型糖尿病和肥胖症，这些合并症会长期增加这些患者的死亡率。皮质醇分泌的轻微变化会影响骨骼健康、生活质量并导致抑郁，但由于临床特征不明显，SCS 患者在过度治疗和治疗不足之间存在风险。本综述旨在总结亚临床库欣综合征患者处理方法的最新建议。
