Yunus M B
Division of Rheumatology, University of Illinois College of Medicine, Peoria 61656.
Compr Ther. 1988 Feb;14(2):54-64.
Spondyloarthropathies are comprised of a number of diseases that have the following features in common: involvement of the spine with sacroiliitis, peripheral arthritis that is frequently asymmetric, absence of rheumatoid nodule, negative rheumatoid factor, and association with HLA-B27. The most important aspect of spondylitis management is a program of regular exercises, aided by nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy. Indomethacin and phenylbutazone are most effective in AS and RS, although the latter drug should be used with care and only after a trial of other NSAIDs. The mainstay of peripheral arthritis management is the use of NSAIDs and intra-articular corticosteroids, but several delayed-acting drugs (gold, cytotoxic drugs) are beneficial in difficult cases, depending on the type and severity of the disease.
累及脊柱伴骶髂关节炎、外周关节炎常不对称、无类风湿结节、类风湿因子阴性以及与 HLA - B27 相关。脊柱炎治疗的最重要方面是定期锻炼计划，辅以非甾体抗炎药（NSAIDs）和物理治疗。吲哚美辛和保泰松在强直性脊柱炎（AS）和赖特综合征（RS）中最有效，尽管后一种药物应谨慎使用，且仅在试用其他 NSAIDs 之后使用。外周关节炎治疗的主要方法是使用 NSAIDs 和关节内注射皮质类固醇，但根据疾病的类型和严重程度，几种起效较慢的药物（金制剂、细胞毒性药物）在难治性病例中有益。
