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重度主动脉瓣狭窄合并大量吸烟情况下的巨大左心室血栓形成

Giant Left Ventricular Thrombus Formation in the Setting of Severe Aortic Stenosis and Heavy Cigarette Smoking.

作者信息

Elmassry Mohamed, Rahman M Rubayat, Dixon Timothy, Rogers Brandon, Nair Nandini

机构信息

Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.

Cardiology, Texas Tech University Health Sciences Center, Lubbock, USA.

出版信息

Cureus. 2020 Jul 11;12(7):e9130. doi: 10.7759/cureus.9130.

DOI:10.7759/cureus.9130
PMID:32789071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7417085/
Abstract

The harmful effects of cigarette smoking on the human body have been well documented. However, whether tobacco use is an independent risk factor of valvular heart disease remains debatable. Cigarette smoking has been associated with an inflammatory state and increased levels of tumor necrosis factor alpha, which in turn activates protein kinases involved in ventricular remodeling. Subsequent ventricular dysfunction predisposes to the formation of mural thrombi which may lead to further worsening of hemodynamics. We present a case of severe aortic stenosis and giant left ventricular thrombus formation associated with chronic cigarette smoking.

摘要

吸烟对人体的有害影响已有充分记载。然而，烟草使用是否为心脏瓣膜病的独立危险因素仍存在争议。吸烟与炎症状态及肿瘤坏死因子α水平升高有关，进而激活参与心室重塑的蛋白激酶。随后的心室功能障碍易引发壁血栓形成，这可能导致血流动力学进一步恶化。我们报告一例与慢性吸烟相关的严重主动脉瓣狭窄及巨大左心室血栓形成的病例。

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1
Giant Left Ventricular Thrombus Formation in the Setting of Severe Aortic Stenosis and Heavy Cigarette Smoking.重度主动脉瓣狭窄合并大量吸烟情况下的巨大左心室血栓形成
Cureus. 2020 Jul 11;12(7):e9130. doi: 10.7759/cureus.9130.
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本文引用的文献

1
Impact of Cumulative Smoking Exposure on Subclinical Degenerative Aortic Valve Disease in Apparently Healthy Male Workers.累积吸烟量对貌似健康男性工人亚临床退行性主动脉瓣疾病的影响。
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Association of Cigarette Smoking With Degenerative Aortic Valve Disease.吸烟与退行性主动脉瓣疾病的关联。
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3
Left ventricular thrombus formation in myocardial infarction is associated with altered left ventricular blood flow energetics.
左心室血栓形成与心肌梗死时左心室血流能量状态改变有关。
Eur Heart J Cardiovasc Imaging. 2019 Jan 1;20(1):108-117. doi: 10.1093/ehjci/jey121.
4
Takotsubo cardiomyopathy complicated with apical thrombus formation on first day of the illness: a case report and literature review.Takotsubo心肌病在发病第一天并发心尖部血栓形成：一例报告及文献复习
BMC Cardiovasc Disord. 2017 Jul 3;17(1):176. doi: 10.1186/s12872-017-0616-0.
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Alcohol consumption, cigarette smoking and incidence of aortic valve stenosis.饮酒、吸烟与主动脉瓣狭窄的发生。
J Intern Med. 2017 Oct;282(4):332-339. doi: 10.1111/joim.12630. Epub 2017 Jun 1.
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Association Between Cardiovascular Risk Factors and Aortic Stenosis: The CANHEART Aortic Stenosis Study.心血管危险因素与主动脉瓣狭窄的关系：CANHEART 主动脉瓣狭窄研究。
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Surgical Extirpation of Apical Left Ventricular Thrombus in Takotsubo Cardiomyopathy.应激性心肌病患者左心室心尖部血栓的手术切除
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Acute effects of cigarette smoking on the cardiac diastolic functions.吸烟对心脏舒张功能的急性影响。
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Transapical extirpation of a left ventricular thrombus in Takotsubo cardiomyopathy.经心尖切除应激性心肌病患者左心室血栓
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10
A rare cause of Takotsubo cardiomyopathy related left ventricular apical thrombus requiring surgery.因罕见病因导致的 Takotsubo 心肌病相关左心室心尖血栓需手术治疗。
Heart Lung Circ. 2012 Apr;21(4):245-6. doi: 10.1016/j.hlc.2011.07.004. Epub 2011 Aug 15.