心力衰竭患者肝功能与峰值摄氧量之间的关联：一项回顾性观察研究。
Association Between Liver Function and Peak Oxygen Uptake in Heart Failure Patients: A Retrospective Observational Study.
作者信息
Hanada Satoru, Kudo Takeaki, Kanzaki Tomohiro, Sakata Koji, Iwakiri Hironao
机构信息
Department of Rehabilitation, Miyakonojo Medical Association Hospital, Miyakonojo, Miyazaki, Japan.
Department of Cardiovascular Medicine, Miyakonojo Medical Association Hospital, Miyakonojo, Miyazaki, Japan.
出版信息
Prog Rehabil Med. 2017 Dec 13;2:20170014. doi: 10.2490/prm.20170014. eCollection 2017.
OBJECTIVE
With respect to liver function and heart failure, 46% of acute decompensated heart failure patients exhibit abnormal liver function. However, there have been no reports of the association between liver function and functional capacity in these patients. Our aim was to clarify the relationship between liver function and functional capacity using the peak oxygen uptake (VO).
METHODS
We retrospectively identified 36 heart failure patients who were referred to our rehabilitation laboratory. These patients underwent cardiopulmonary exercise testing (CPX). Furthermore, we investigated the correlations between peak VO, blood measurements [e.g., total bilirubin (T-bil) and brain natriuretic peptide], and echocardiographic parameters. Finally, multivariate regression analysis was performed to investigate the independent variables related to peak VO.
RESULTS
The mean peak VO was 10.7±2.9 ml/kg/min. Peak VO during CPX correlated inversely with T-bil [r=-0.379, 95% confidence intervals (CI): -0.654 to -0.014, P=0.043], aspartate transaminase (r=-0.426, 95% CI: -0.685 to -0.07, P=0.021), and peak heart rate (r=0.391, 95% CI: 0.029 to 0.663, P=0.036). The significant independent factors associated with peak VO were treatment with statin (β=-3.19, P=0.015) and T-bil levels (β=-4.27, P=0.002).
CONCLUSION
Our findings demonstrated that liver function may contribute to the functional capacity in heart failure patients.
目的
在肝功能与心力衰竭方面，46%的急性失代偿性心力衰竭患者存在肝功能异常。然而，尚无关于这些患者肝功能与功能能力之间关联的报道。我们的目的是通过峰值摄氧量（VO₂）来阐明肝功能与功能能力之间的关系。
方法
我们回顾性确定了36名转诊至我们康复实验室的心力衰竭患者。这些患者接受了心肺运动试验（CPX）。此外，我们研究了峰值VO₂、血液检测指标（如总胆红素（T-bil）和脑钠肽）以及超声心动图参数之间的相关性。最后，进行多变量回归分析以研究与峰值VO₂相关的独立变量。
结果
平均峰值VO₂为10.7±2.9 ml/kg/min。CPX期间的峰值VO₂与T-bil呈负相关[r=-0.379，95%置信区间（CI）：-0.654至-0.014，P=0.043]，与天冬氨酸转氨酶呈负相关（r=-0.426，95%CI：-0.685至-0.07，P=0.021），与峰值心率呈正相关（r=0.391，95%CI：0.029至0.663，P=0.036）。与峰值VO₂相关的显著独立因素是他汀类药物治疗（β=-3.19，P=0.015）和T-bil水平（β=-4.27，P=0.002）。
结论
我们的研究结果表明，肝功能可能影响心力衰竭患者的功能能力。
Zotero 插件