Homma Yuki, Fukuda Kazuishi, Iwasawa Nobuharu, Takaya Jun
Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
Chem Commun (Camb). 2020 Sep 15;56(73):10710-10713. doi: 10.1039/d0cc02889d.
Efficient synthesis of o-borylphenols is achieved through the Ru-catalyzed regio- and site-selective sp2 C-H borylation of aryl diphenylphosphinites followed by removal of the phosphorus directing group. A successful application to aryl phosphites enables practical one-pot borylation of phenols, demonstrating high synthetic utility of this protocol.
通过钌催化的芳基二苯基次膦酸酯的区域和位点选择性sp2 C-H硼化反应，然后除去磷导向基团，实现了邻硼基苯酚的高效合成。该方法成功应用于亚磷酸芳基酯，实现了苯酚的实用一锅法硼化反应，证明了该方案具有很高的合成实用性。
