Reimer R R, Chabner B A, Young R C, Reddick R, Johnson R E
Ann Intern Med. 1977 Jul;87(1):50-5. doi: 10.7326/0003-4819-87-1-50.
Lymphoma presenting in bone (that is "reticulum cell sarcoma of bone") is a form of extranodal lymphoma historically described as frequently localized (this is, stage IE or stage IIE). Between 1970 and 1975, 14 patients with this entity were seen at the National Cancer Institute. This group had a variety of histologic subtypes of diffuse lymphoma. Thorough staging showed extensive disease (stage IV) in 12 of these patients (86%). In 10 of these the metastatic disease was unsuspected clinically. Seven patients achieved complete remissions after treatment was combination chemotherapy alone (two patients), irradiation alone (one patient), surgery alone (one patient), and both chemotherapy and irradiation (three patients) and are alive and free of disease 11 + to 70 + months after diagnosis. The other seven patients did not achieve complete remission status and have all died. Although lymphomas presenting in bone may occasionally be localized, careful staging in this series frequently showed extensive disease and altered the therapeutic approach.
原发于骨的淋巴瘤（即“骨网状细胞肉瘤”）是一种结外淋巴瘤，历史上曾被描述为常为局限性（即IE期或IIE期）。1970年至1975年间，美国国立癌症研究所共诊治了14例该疾病患者。该组患者有多种弥漫性淋巴瘤的组织学亚型。全面分期显示，其中12例患者（86%）有广泛病变（IV期）。其中10例患者临床上未怀疑有转移性疾病。7例患者在接受单纯联合化疗（2例）、单纯放疗（1例）、单纯手术（1例）以及化疗和放疗联合治疗（3例）后实现完全缓解，诊断后11个月至70个月以上仍存活且无疾病。其他7例患者未达到完全缓解状态，均已死亡。尽管原发于骨的淋巴瘤偶尔可能为局限性，但本系列研究中的仔细分期常显示有广泛病变，并改变了治疗方法。
