The Impact of Apolipoprotein E Genetic Variability in Health and Life Span.
作者信息
Raghavachari Nalini
机构信息
Division of Geriatrics and Clinical Gerontology, National Institute on Aging, NIH, Bethesda, Maryland.
出版信息
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1855-1857. doi: 10.1093/gerona/glaa175.
Abstract
摘要
相似文献
1
The Impact of Apolipoprotein E Genetic Variability in Health and Life Span.载脂蛋白E基因变异性对健康和寿命的影响。
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1855-1857. doi: 10.1093/gerona/glaa175.
2
Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang.新疆维吾尔族载脂蛋白E基因多态性及其与人类长寿的关联
Chin Med J (Engl). 2001 Aug;114(8):817-20.
3
[Relationship between blood lipid level and apolipoprotein E gene polymorphism in offspring from longevity and non-longevity families].长寿与非长寿家庭后代血脂水平与载脂蛋白E基因多态性的关系
Zhonghua Yu Fang Yi Xue Za Zhi. 2000 May;34(3):159-61.
4
[Polymorphism of apolipoprotein E gene and natural longevity in the Xinjiang Uighur people: an association study].[新疆维吾尔族人群载脂蛋白E基因多态性与自然长寿的关联研究]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Aug;22(4):462-3.
5
Analysis of common polymorphisms in angiotensin-converting enzyme and apolipoprotein e genes and human longevity in Colombia.哥伦比亚血管紧张素转换酶和载脂蛋白E基因常见多态性与人类长寿的分析。
Arch Med Res. 2006 Oct;37(7):890-4. doi: 10.1016/j.arcmed.2006.04.001.
6
[Genetic factors in longevity].[长寿中的遗传因素]
Presse Med. 2003 Mar 1;32(8):365-9.
7
Apolipoprotein E and B polymorphisms--longevity factors assessed in nonagenarians.载脂蛋白E和B基因多态性——在九旬老人中评估的长寿因素。
Atherosclerosis. 1994 Jan;105(1):89-95. doi: 10.1016/0021-9150(94)90011-6.
8
Interleukin 6-174 G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interaction with apolipoprotein E alleles.百岁老人白细胞介素6 - 174 G/C启动子基因多态性：无证据表明与人类长寿相关或与载脂蛋白E等位基因存在相互作用。
Exp Gerontol. 2004 Jul;39(7):1109-14. doi: 10.1016/j.exger.2004.03.037.
9
Genetic associations with human longevity at the APOE and ACE loci.载脂蛋白E（APOE）和血管紧张素转换酶（ACE）基因座与人类长寿的遗传关联。
Nat Genet. 1994 Jan;6(1):29-32. doi: 10.1038/ng0194-29.
10
Methodological problems in genetic association studies of longevity--the apolipoprotein E gene as an example.长寿基因关联研究中的方法学问题——以载脂蛋白E基因为例。
Int J Epidemiol. 2004 Oct;33(5):962-70. doi: 10.1093/ije/dyh214. Epub 2004 Aug 19.
引用本文的文献
1
Bioinformatic and genomic analysis identifies C allele of APOE rs7412 as the most prominent variant limiting extreme human longevity.生物信息学和基因组分析确定，载脂蛋白E基因（APOE）rs7412位点的C等位基因为限制人类极端长寿的最主要变异。
Sci Rep. 2025 Jul 1;15(1):21688. doi: 10.1038/s41598-025-02848-5.
2
Biomarkers selection and mathematical modeling in biological age estimation.生物年龄估计中的生物标志物选择与数学建模
NPJ Aging. 2023 Jul 1;9(1):13. doi: 10.1038/s41514-023-00110-8.
3
Genome-wide association studies for Alzheimer's disease: bigger is not always better.阿尔茨海默病的全基因组关联研究：规模越大未必越好。
Brain Commun. 2022 May 17;4(3):fcac125. doi: 10.1093/braincomms/fcac125. eCollection 2022.
4
Genes and Longevity of Lifespan.基因与寿命的长短。
Int J Mol Sci. 2022 Jan 28;23(3):1499. doi: 10.3390/ijms23031499.
本文引用的文献
1
APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline.载脂蛋白 E ε4 及性别、年龄、血管危险因素和种族对认知能力下降的影响。
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1863-1873. doi: 10.1093/gerona/glaa116.
2
Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project.载脂蛋白 E 与老年男性健康：康科德健康与男性衰老研究项目。
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1858-1862. doi: 10.1093/gerona/glaa105.
3
Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.体力活动对 APOE 与老年人认知能力下降相关性的调节作用：三项纵向队列研究的结果。
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1880-1886. doi: 10.1093/gerona/glaa054.
4
APOE ε4 Carriers Have a Greater Propensity to Glycation and sRAGE Which Is Further Influenced by RAGE G82S Polymorphism.载脂蛋白 E ε4 携带者更容易发生糖基化和 sRAGE，而 RAGE G82S 多态性进一步影响了这一过程。
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1899-1905. doi: 10.1093/gerona/glz259.
5
Sex-Specific Effects of Apolipoprotein ε4 Allele on Mortality in Very Old and Centenarian Japanese Men.载脂蛋白 E4 等位基因对极老年和百岁日本男性死亡率的性别特异性影响。
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1874-1879. doi: 10.1093/gerona/glz242.
6
ApoE Genotype, Lipid Profile, Exercise, and the Associations With Cardiovascular Morbidity and 18-Year Mortality.载脂蛋白 E 基因型、血脂谱、运动与心血管发病率和 18 年死亡率的关系。
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1887-1893. doi: 10.1093/gerona/glz232.
7
Shorter Telomere Length in Carriers of APOE-ε4 and High Plasma Concentration of Glucose, Glyoxal and Other Advanced Glycation End Products (AGEs).APOE-ε4 携带者的端粒较短，且其血浆中葡萄糖、甘油醛和其他晚期糖基化终产物（AGEs）浓度较高。
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1894-1898. doi: 10.1093/gerona/glz203.
8
APOE Alleles and Extreme Human Longevity.载脂蛋白 E 等位基因与人类极端长寿。
J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):44-51. doi: 10.1093/gerona/gly174.
9
Apolipoprotein E - A Multifunctional Protein with Implications in Various Pathologies as a Result of Its Structural Features.载脂蛋白E——一种多功能蛋白质，因其结构特征而与多种病理状况相关。
Comput Struct Biotechnol J. 2017 Jun 6;15:359-365. doi: 10.1016/j.csbj.2017.05.003. eCollection 2017.
10
Apolipoprotein E Isoforms and AMD.载脂蛋白E异构体与年龄相关性黄斑变性
Adv Exp Med Biol. 2016;854:3-9. doi: 10.1007/978-3-319-17121-0_1.
Zotero 插件