Mayila Wufuer, Fang Ming-wu, Cheng Zu-heng, Qiu Chang-chun
Cardiology Department of Internal Medicine, the First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830054 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Aug;22(4):462-3.
To explore the distribution of polymorphisms of apolipoprotein E(apoE) gene and its relation to natural longevity in the Xinjiang Uighur people.
Using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP), the authors obtained data from centenarians(n=42), 90-year-old people (n=102), 65-70-year-old people (n=70) and controls(n=53).
The frequencies of apoE genotypes epsilon 3/4, epsilon 3/3 and epsilon 2/3 were 2.4%, 69.0% and 23.8% respectively in the centenarian group, and the frequencies of their epsilon 4, epsilon 3 and epsilon 2 alleles were 1.2%, 82.1% and 16.7%. The frequencies of genotype epsilon 3/4 and epsilon 4, epsilon 3 allele in the centenarian group were significantly lower than those in controls(P< 0.01), whereas the frequencies of genotype epsilon 2/3 and epsilon 2 allele in the centenarian group were significantly higher than those in controls(P< 0.01). Longevity was noted to be positively correlated with epsilon 2 and negatively correlated with epsilon 4.
This relationship reflects a genetic influence on differential survival and may point to pleiotropic age-dependent effects on longevity.
探讨新疆维吾尔族人群载脂蛋白E（apoE）基因多态性分布及其与自然长寿的关系。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术，作者获取了来自百岁老人（n = 42）、90岁人群（n = 102）、65 - 70岁人群（n = 70）和对照组（n = 53）的数据。
百岁老人组中apoE基因型ε3/4、ε3/3和ε2/3的频率分别为2.4%、69.0%和23.8%，其ε4、ε3和ε2等位基因的频率分别为1.2%、82.1%和16.7%。百岁老人组中基因型ε3/4和ε4、ε3等位基因的频率显著低于对照组（P < 0.01），而百岁老人组中基因型ε2/3和ε2等位基因的频率显著高于对照组（P < 0.01）。发现长寿与ε2呈正相关，与ε4呈负相关。
这种关系反映了基因对不同生存情况的影响，可能表明存在对长寿的多效性年龄依赖性效应。
