前列腺特异性膜抗原（PSMA）在前列腺癌原发分期及生化复发中的全身肿瘤负荷
PSMA whole-body tumor burden in primary staging and biochemical recurrence of prostate cancer.
作者信息
Santos Allan, Mattiolli Aline, Carvalheira José Bc, Ferreira Ubirajara, Camacho Mariana, Silva Cleide, Costa Fernanda, Matheus Wagner, Lima Mariana, Etchebehere Elba
机构信息
Medicina Nuclear de Campinas, Campinas, São Paulo, Brazil.
Division of Nuclear Medicine of the Department of Radiology, Campinas State University (UNICAMP), Rua Vital Brazil 251, Campinas, 13083-888, Brazil.
出版信息
Eur J Nucl Med Mol Imaging. 2021 Feb;48(2):493-500. doi: 10.1007/s00259-020-04981-x. Epub 2020 Aug 13.
PURPOSE
The objective of this study was to evaluate whether Ga-PSMA PET/CT whole-body tumor burden (PSMAwbtb) is associated with clinical parameters and laboratory parameters in prostate cancer patients.
METHODS
We retrospectively evaluated prostate cancer patients submitted to PSMA PET/CT for primary staging purposes or due to biochemical recurrence (BR). PSMAwbtb metrics (total volume of PSMA-avid tumor (PSMA-TV)) and total uptake of PSMA-avid lesions (PSMA-TL) were calculated semi-automatically. Spearman's rank correlations between PSMAwbtb metrics and clinical, laboratory parameters (age, time-to-BR, years of diagnosis of prostate cancer, free and total serum PSA levels, and the Gleason score) and with the highest SUVmax of a lesion (hSUVmax) were analyzed.
RESULTS
Among the 257 PSMA PET/CT studies, there were 46 scans (17.9%) performed for primary staging and 211 (82.1%) for BR. PSMA-TV and PSMA-TL were calculated for the 157 positive scans (58.8%), which were 43 patients (93.5%) in the primary staging group and 114 patients (54.0%) in the BR group. In the primary staging group, we observed a significant correlation between PSMA-TL and hSUVmax (p = 0.0021). In the BR group, there was a significant direct correlation between PSMA-TL and the variables age (p = 0.0031), total serum PSA values (p = < 0.0001), free serum PSA values (p = < 0.0001), and the hSUVmax (p = < 0.0001). Similar results were obtained for PSMA-TV.
CONCLUSION
PSMAwbtb has a direct and positive correlation with serum PSA values and age in prostate cancer patients with BR.
目的
本研究的目的是评估镓-前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描（Ga-PSMA PET/CT）全身肿瘤负荷（PSMAwbtb）是否与前列腺癌患者的临床参数和实验室参数相关。
方法
我们回顾性评估了因初次分期或生化复发（BR）而接受PSMA PET/CT检查的前列腺癌患者。半自动计算PSMAwbtb指标（PSMA阳性肿瘤总体积（PSMA-TV））和PSMA阳性病变的总摄取量（PSMA-TL）。分析PSMAwbtb指标与临床、实验室参数（年龄、至BR时间、前列腺癌诊断年限、游离和总血清前列腺特异抗原（PSA）水平以及 Gleason评分）以及与病变的最高标准化摄取值（hSUVmax）之间的Spearman等级相关性。
结果
在257例PSMA PET/CT检查中，有46例扫描（17.9%）用于初次分期，211例（82.1%）用于BR。对157例阳性扫描（58.8%）计算了PSMA-TV和PSMA-TL，其中初次分期组有43例患者（93.5%），BR组有114例患者（54.0%）。在初次分期组中，我们观察到PSMA-TL与hSUVmax之间存在显著相关性（p = 0.0021）。在BR组中，PSMA-TL与年龄（p = 0.0031）、总血清PSA值（p = < 0.0001）、游离血清PSA值（p = < 0.0001）以及hSUVmax（p = < 0.0001）之间存在显著正相关。PSMA-TV也得到了类似结果。
结论
在BR的前列腺癌患者中，PSMAwbtb与血清PSA值和年龄呈直接正相关。
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