Caldaria Antonio, Giuffrida Roberta, di Meo Nicola, Massari Leo, Dianzani Caterina, Cannavò Serafinella Patrizia, Degrassi Ferruccio, Casablanca Edoardo, Zalaudek Iris, Conforti Claudio
Orthopedic and Traumatology Unit, Sant'Anna University Hospital, Ferrara, Italy.
Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, Italy.
Dermatol Ther. 2020 Nov;33(6):e14193. doi: 10.1111/dth.14193. Epub 2020 Sep 10.
Bone is the fourth most common site of melanoma metastasis after lung, liver, and brain. Melanoma bone metastases typically occur in patients who already have widespread metastases in other organs. Current available approaches for bone metastases from melanoma include chemotherapy, radiotherapy, biological therapy, combination therapy, and surgery. In this narrative review, we describe the management of patients affected by melanoma bone metastases, discussing the diagnostic and treatment approaches as well as their impact on survival and quality of life. Despite the fact that clinical and surgical trials will be required to determine the most appropriate treatment, we do expect a newer and more important role of multidisciplinary approach in the management of melanoma patients with bone metastases in the next future.
骨骼是黑色素瘤转移的第四大常见部位，仅次于肺、肝和脑。黑色素瘤骨转移通常发生在其他器官已有广泛转移的患者中。目前针对黑色素瘤骨转移的可用方法包括化疗、放疗、生物治疗、联合治疗和手术。在这篇叙述性综述中，我们描述了受黑色素瘤骨转移影响患者的管理，讨论了诊断和治疗方法以及它们对生存和生活质量的影响。尽管需要进行临床试验来确定最合适的治疗方法，但我们确实预计在未来，多学科方法在黑色素瘤骨转移患者的管理中将发挥更新且更重要的作用。
