Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.
Zoetis UK, Springfield Drive, Leatherhead, United Kingdom.
PLoS One. 2020 Aug 13;15(8):e0236143. doi: 10.1371/journal.pone.0236143. eCollection 2020.
The focus of gastro-intestinal parasite control in the sheep industry is increasingly on finding a balance between maintaining productivity of the flock whilst minimising selection for anthelmintic resistance to preserve anthelmintic efficacy for the future. Periparturient ewes represent the major source of gastro-intestinal parasites for growing lambs and are therefore a priority for parasite control. This study examines the impact on ewe faecal egg counts (FECs), lamb FECs, lamb daily live weight gains (DLWGs) and pasture larval counts of treating groups of ewes two weeks prior to lambing with either, a long-acting moxidectin treatment, short-acting doramectin or control. Six groups of twenty ewes were allocated to individual paddocks, two groups allocated to each treatment, and weekly faecal sampling was performed throughout from the ewes and from six weeks after the start of lambing in the lambs. Treatment group was found to have a significant effect on both ewe FEC (p<0.001) and lamb FEC (p = 0.001) with the group receiving the long-acting anthelmintic having the lowest ewe and lamb FECs. There was no significant effect on the DLWGs of the lambs. Pasture larval counts at the end of the study period were lowest in the long-acting wormer treatment group. The use of long-acting moxidectin may be helpful as part of a parasite control programme by reducing the worm burdens of ewes and their lambs, decreasing the number of anthelmintic treatments required in that year and by reducing pasture contamination for those sheep which will graze the pasture in the next year. However, like all anthelmintics, its use should be judicious to avoid selection for resistance.
胃肠道寄生虫控制在绵羊产业中的重点越来越集中在寻找一种平衡,即在最小化选择驱虫剂耐药性的同时保持羊群的生产力,以保留驱虫剂的未来效果。围产期母羊是羔羊胃肠道寄生虫的主要来源,因此是寄生虫控制的优先事项。本研究检查了在产羔前两周用长效莫昔克丁处理、短效多拉菌素或对照处理组对母羊粪便卵囊计数 (FEC)、羔羊 FEC、羔羊日增重 (DLWG) 和牧场幼虫计数的影响。将 60 只母羊分为 20 个组,分配到单独的围场中,每组分配到 2 个处理组,并从母羊和羔羊产羔开始后的第六周开始每周进行粪便采样。处理组对母羊 FEC(p<0.001)和羔羊 FEC(p=0.001)均有显著影响,接受长效驱虫剂处理的母羊和羔羊的 FEC 最低。对羔羊的 DLWG 没有显著影响。研究结束时,长效驱虫剂处理组牧场幼虫计数最低。长效莫昔克丁的使用可能有助于作为寄生虫控制计划的一部分,通过降低母羊及其羔羊的蠕虫负担、减少当年所需的驱虫剂治疗次数以及减少来年将在牧场上放牧的绵羊的牧场污染来减少寄生虫负担。然而,与所有驱虫剂一样,应谨慎使用,以避免耐药性的选择。