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用于乳腺 X 光筛查和诊断的新型卷积神经网络模型。

New convolutional neural network model for screening and diagnosis of mammograms.

机构信息

College of Information and Computer, Taiyuan University of Technology, Taiyuan, Shanxi, China.

Technology Research Center of Spatial Information Network Engineering of Shanxi, Taiyuan, Shanxi, China.

出版信息

PLoS One. 2020 Aug 13;15(8):e0237674. doi: 10.1371/journal.pone.0237674. eCollection 2020.

DOI:10.1371/journal.pone.0237674
PMID:32790772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7425967/
Abstract

Breast cancer is the most common cancer in women and poses a great threat to women's life and health. Mammography is an effective method for the diagnosis of breast cancer, but the results are largely limited by the clinical experience of radiologists. Therefore, the main purpose of this study is to perform two-stage classification (Normal/Abnormal and Benign/Malignancy) of two- view mammograms through convolutional neural network. In this study, we constructed a multi-view feature fusion network model for classification of mammograms from two views, and we proposed a multi-scale attention DenseNet as the backbone network for feature extraction. The model consists of two independent branches, which are used to extract the features of two mammograms from different views. Our work mainly focuses on the construction of multi-scale convolution module and attention module. The final experimental results show that the model has achieved good performance in both classification tasks. We used the DDSM database to evaluate the proposed method. The accuracy, sensitivity and AUC values of normal and abnormal mammograms classification were 94.92%, 96.52% and 94.72%, respectively. And the accuracy, sensitivity and AUC values of benign and malignant mammograms classification were 95.24%, 96.11% and 95.03%, respectively.

摘要

乳腺癌是女性最常见的癌症,对女性的生命和健康构成了极大的威胁。乳腺 X 线摄影是诊断乳腺癌的有效方法,但结果在很大程度上受到放射科医生临床经验的限制。因此,本研究的主要目的是通过卷积神经网络对双视图乳腺 X 线照片进行两阶段分类(正常/异常和良性/恶性)。在这项研究中,我们构建了一个用于从两个视图分类乳腺 X 线照片的多视图特征融合网络模型,并提出了一个多尺度注意 DenseNet 作为特征提取的骨干网络。该模型由两个独立的分支组成,用于从不同视图提取两张乳腺 X 线照片的特征。我们的工作主要集中在多尺度卷积模块和注意模块的构建上。最终的实验结果表明,该模型在两个分类任务中都取得了良好的性能。我们使用 DDSM 数据库来评估所提出的方法。正常和异常乳腺 X 线照片分类的准确率、敏感度和 AUC 值分别为 94.92%、96.52%和 94.72%,良性和恶性乳腺 X 线照片分类的准确率、敏感度和 AUC 值分别为 95.24%、96.11%和 95.03%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e3/7425967/645c3235da49/pone.0237674.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e3/7425967/51c9ce64dd1b/pone.0237674.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e3/7425967/507e63a7ab5f/pone.0237674.g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e3/7425967/b74c05c43a6c/pone.0237674.g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14e3/7425967/ca3158c75adb/pone.0237674.g003.jpg
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