Hicks B C, Weber P J, Hashimoto K, Ito K, Koreman D M
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL.
J Am Acad Dermatol. 1988 Jan;18(1 Pt 1):19-25. doi: 10.1016/s0190-9622(88)70002-x.
Several patterns of primary cutaneous amyloidosis are recognized; in this report of four cases, we define a new pattern in which the lesions are composed of small papules grouped on the concha of the ear. The lesions typically are not pruritic but slightly friable. They may be present on both ears. The patients do not have lesions of amyloidosis on other parts of the body and no known insult precedes the appearance of lesions. This entity appears to have been described previously as collagenous papules of the ear. Histochemical and electron microscopic methods allow us to confirm the amyloid nature of the substance. We believe this condition to be a variant of primary cutaneous amyloidosis, particularly because monoclonal antikeratin antibody EKH4, which has been positive in lichenoid, macular, and skin epithelial tumor-associated amyloidoses, was positive in our cases.
原发性皮肤淀粉样变有多种类型；在本报告的4例病例中，我们定义了一种新的类型，其损害由聚集在耳甲上的小丘疹组成。这些损害通常无瘙痒感，但稍易脆。双耳均可出现。患者身体其他部位无淀粉样变损害，且损害出现前无已知的损伤。该实体之前似乎被描述为耳部胶原性丘疹。组织化学和电子显微镜方法使我们能够证实该物质的淀粉样本质。我们认为这种情况是原发性皮肤淀粉样变的一种变体，特别是因为在苔藓样、斑状和皮肤上皮肿瘤相关淀粉样变中呈阳性的单克隆抗角蛋白抗体EKH4在我们的病例中也呈阳性。
