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苔藓样淀粉样变的一种泛发性、非瘙痒性变体:一例报告及简要综述。

A generalized, non-pruritic variant of lichen amyloidosis: a case report and a brief review.

作者信息

Kandhari Rajat, Ramesh V, Singh Avninder

机构信息

Department of Dermatology and STD, Safdarjung Hospital, New Delhi, India.

出版信息

Indian J Dermatol. 2013 Jul;58(4):328. doi: 10.4103/0019-5154.113995.

DOI:10.4103/0019-5154.113995
PMID:23919033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3726910/
Abstract

Lichen amyloidosis (LA) has been considered a highly pruritic dermatosis, and the deposition of fibrillar material has generally been considered to be secondary to the scratching. Focal epidermal damage and chronic scratching have been implicated as the pathogenetic factors in the occurrence of LA, although they may not be able to explain the occurrence of a widespread variant of this dermatosis. There are few case reports describing the occurrence of a non-pruritic variant of LA. We hereby report a case of non-pruritic, generalized variant of lichen amyloidosis.

摘要

苔藓样淀粉样变(LA)一直被认为是一种高度瘙痒的皮肤病,通常认为纤维状物质的沉积继发于搔抓。尽管局灶性表皮损伤和慢性搔抓可能无法解释这种皮肤病广泛型的发生,但它们被认为是LA发病的致病因素。很少有病例报告描述LA非瘙痒型的发生。我们在此报告一例非瘙痒性、泛发性苔藓样淀粉样变病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c13/3726910/5ffadf775e67/IJD-58-328e-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c13/3726910/565b802706dd/IJD-58-328e-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c13/3726910/8567395daaf5/IJD-58-328e-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c13/3726910/16cb87171d57/IJD-58-328e-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c13/3726910/5ffadf775e67/IJD-58-328e-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c13/3726910/565b802706dd/IJD-58-328e-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c13/3726910/8567395daaf5/IJD-58-328e-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c13/3726910/16cb87171d57/IJD-58-328e-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c13/3726910/5ffadf775e67/IJD-58-328e-g004.jpg

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本文引用的文献

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Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis.寡聚物在原发性皮肤淀粉样变性的淀粉样生成中的作用。
J Am Acad Dermatol. 2011 Nov;65(5):1023-31. doi: 10.1016/j.jaad.2010.09.735. Epub 2011 Jun 12.
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Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation.淀粉样蛋白生成机制:成核依赖性原纤维形成与双协同原纤维形成
BMB Rep. 2009 Sep 30;42(9):541-51. doi: 10.5483/bmbrep.2009.42.9.541.
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New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis.
从家族性原发性局限性皮肤淀粉样变性的分子研究中对瘙痒机制的新认识。
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Unexpected diminished innervation of epidermis and dermoepidermal junction in lichen amyloidosus.淀粉样变苔藓中表皮和真皮表皮交界处意外的神经支配减少。
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Lichen amyloidosus without itching indicates that it is not secondary to chronic scratching.无瘙痒的淀粉样变苔藓表明它并非继发于慢性搔抓。
Acta Derm Venereol. 2006;86(6):561-2. doi: 10.2340/00015555-0155.
6
Pretibial pruritic papular dermatitis: A distinctive cutaneous manifestation in response to chronic rubbing.胫前瘙痒性丘疹性皮炎:一种因慢性摩擦而产生的独特皮肤表现。
Am J Dermatopathol. 2006 Apr;28(2):117-21. doi: 10.1097/01.dad.0000200017.37082.e4.
7
Thermosensitive lichen amyloidosis.热敏性苔藓样淀粉样变病。
Int J Dermatol. 2004 Dec;43(12):925-8. doi: 10.1111/j.1365-4632.2004.02273.x.
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Lichen amyloidosus with subepidermal blister formation.伴有表皮下疱形成的淀粉样变苔藓。
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Generalized lichen amyloidosus associated with chronic urticaria.与慢性荨麻疹相关的泛发性苔藓样淀粉样变。
Dermatology. 2003;207(2):203-4. doi: 10.1159/000071798.