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Urine: A Lens for Asthma Pathogenesis and Treatment?

作者信息

Peebles R Stokes

机构信息

Department of Medicine Vanderbilt University School of Medicine Nashville, Tennessee.

出版信息

Am J Respir Crit Care Med. 2021 Jan 1;203(1):1-3. doi: 10.1164/rccm.202007-2899ED.

DOI:10.1164/rccm.202007-2899ED
PMID:32791002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7781120/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9146/7781120/31cb8affcfdf/rccm.202007-2899EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9146/7781120/31cb8affcfdf/rccm.202007-2899EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9146/7781120/31cb8affcfdf/rccm.202007-2899EDf1.jpg

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Aspirin-intolerant asthma (AIA) assessment using the urinary biomarkers, leukotriene E4 (LTE4) and prostaglandin D2 (PGD2) metabolites.使用尿生物标志物白三烯 E4(LTE4)和前列腺素 D2(PGD2)代谢物评估阿司匹林不耐受性哮喘(AIA)。
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本文引用的文献

1
Urinary Leukotriene E and Prostaglandin D Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study.尿白三烯 E 和前列腺素 D 代谢物在 2 型炎症为主的成人和儿童重症哮喘中增加。一项临床观察研究。
Am J Respir Crit Care Med. 2021 Jan 1;203(1):37-53. doi: 10.1164/rccm.201909-1869OC.
2
Prostaglandins in asthma and allergic diseases.哮喘和过敏性疾病中的前列腺素。
Pharmacol Ther. 2019 Jan;193:1-19. doi: 10.1016/j.pharmthera.2018.08.001. Epub 2018 Aug 3.
3
Cysteinyl leukotriene E activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D and epithelial cytokines.
半胱氨酰白三烯E激活人类2型固有淋巴细胞并增强前列腺素D和上皮细胞因子的作用。
J Allergy Clin Immunol. 2017 Oct;140(4):1090-1100.e11. doi: 10.1016/j.jaci.2016.12.958. Epub 2017 Jan 20.
4
Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype.前列腺素E2在肺部的抗炎作用:EP4受体亚型的作用
Thorax. 2015 Aug;70(8):740-7. doi: 10.1136/thoraxjnl-2014-206592. Epub 2015 May 4.
5
Enhanced innate type 2 immune response in peripheral blood from patients with asthma.哮喘患者外周血中增强的固有2型免疫反应。
J Allergy Clin Immunol. 2014 Sep;134(3):671-678.e4. doi: 10.1016/j.jaci.2014.06.024.
6
Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells.前列腺素 D2 通过表达在 TH2 细胞上的趋化因子受体同源分子激活 2 型固有淋巴细胞。
J Allergy Clin Immunol. 2014 Apr;133(4):1184-94. doi: 10.1016/j.jaci.2013.10.056. Epub 2013 Dec 31.
7
Resolution of acute inflammation in the lung.肺部急性炎症的消退。
Annu Rev Physiol. 2014;76:467-92. doi: 10.1146/annurev-physiol-021113-170408. Epub 2013 Dec 2.
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A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst.一种新型的CRTH2拮抗剂可阻断嗜酸性粒细胞从骨髓的释放、趋化作用和呼吸爆发。
Allergy. 2007 Dec;62(12):1401-9. doi: 10.1111/j.1398-9995.2007.01452.x. Epub 2007 Aug 21.
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