Rogozina M I, Gurleva G G, Ryzhko V, Makarovskaia L N, Pun'ko T A
Antibiotiki. 1977 May;22(5):455-7.
227 out of 228 strains of pseudotuberculosis microbes studied in vitro proved to be sensitive to tetracyclines. The MIC of tetracycline and morphocycline ranged within 0.25--25 gamma/ml. The MIC of chlortetracycline and oxytetracycline was somewhat lower, i. e. 1--50 gamma/ml. When administered intramuscularly all the tetracyclines had pronounced therapeutic effect in experiments with albino mice infected with the antibiotic sensitive strains of J. pseudotuberculosis. Chlortetracycline proved to be the most active drug in treatment of albino mice per os.
在体外研究的228株假结核微生物中，有227株被证明对四环素敏感。四环素和莫西环素的最低抑菌浓度范围在0.25--25微克/毫升之间。金霉素和土霉素的最低抑菌浓度略低，即1--50微克/毫升。在对白化小鼠进行的实验中，当肌肉注射时，所有四环素对感染抗生素敏感的假结核耶尔森菌菌株均有显著治疗效果。在对白化小鼠进行口服治疗时，金霉素被证明是最有效的药物。
