通过单次注射、双样本法，利用锝-99m二乙三胺五乙酸血浆清除率估算细胞外液量。
Estimation of extracellular fluid volume from plasma clearance on technetium-99m DTPA by a single-injection, two-sample method.
作者信息
Russell C D, Bischoff P G, Rowell K L, Lloyd L K, Dubovsky E V
机构信息
Division of Nuclear Medicine, University of Alabama Hospital, Birmingham 35233.
出版信息
J Nucl Med. 1988 Feb;29(2):255-8.
A simple method is presented for estimating extracellular fluid volume from the plasma clearance of [99mTc])DTPA or [169Yb]DTPA. Two plasma samples are required, at 1 and 3 hr, following a single intravenous injection. (The same plasma samples can be used for measurement of glomerular filtration rate.) Using the complete plasma clearance curve as a reference (eight samples at 10 to 240 min), the error of the two-sample method in 40 patients was 1.5 I for [99mTc]DTPA, 2.1 I for [169Yb]DTPA (residual standard deviation).
本文介绍了一种通过[99mTc]二乙三胺五乙酸（DTPA）或[169Yb]DTPA的血浆清除率估算细胞外液量的简单方法。单次静脉注射后，需要在1小时和3小时采集两份血浆样本。（相同的血浆样本可用于测量肾小球滤过率。）以完整的血浆清除率曲线作为参考（在10至240分钟采集8份样本），40例患者采用双样本法时，[99mTc]DTPA的误差为1.5升，[169Yb]DTPA的误差为2.1升（剩余标准差）。
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