Department of Neurology, Headache Outpatient Clinic, Medical University of Innsbruck, Innsbruck, Austria.
Department of Sport Science, Leopold-Franzens University of Innsbruck, Innsbruck, Austria.
Cephalalgia. 2020 Dec;40(14):1561-1573. doi: 10.1177/0333102420949202. Epub 2020 Aug 13.
For future experimental studies or the development of targeted pharmaceutical agents, a deeper insight into the pathophysiology of migraine is of utmost interest. Reliable methods to trigger migraine attacks including aura are desirable to study this complex disease .
To investigate hypoxia as a trigger for migraine and aura, we exposed volunteers diagnosed with migraine, with (n = 16) and without aura (n = 14), to hypoxia utilizing a hypoxic chamber adjusted to a FiO of 12.6%. The occurrence of headache, migraine, aura, and accompanying symptoms were registered and vital signs were collected for 6 hours under hypoxia and 2 hours of follow-up. A binary logistic regression analysis examined the probability of triggering headaches, migraines, aura, photo- and phonophobia.
Of 30 participants, 24 (80.0%) developed headaches and 19 (63.3%) migraine, five (16.7%) reported aura. Two patients that developed aura never experienced aura symptoms before in their life. The increase of mean heart frequency was higher in patients developing headaches or migraine. Mean SpO during hypoxia was 83.39%.
Hypoxia was able to trigger migraine attacks and aura independently of any pharmacological agent.
为了未来的实验研究或靶向药物制剂的开发，深入了解偏头痛的病理生理学是极其重要的。可靠的方法来引发偏头痛发作，包括先兆，是研究这种复杂疾病所需要的。
为了研究缺氧作为偏头痛和先兆的触发因素，我们利用调整到 FiO2 为 12.6%的缺氧室，使被诊断为偏头痛的志愿者（有先兆组，n=16；无先兆组，n=14）暴露于缺氧环境中。记录头痛、偏头痛、先兆以及伴随症状的发生，并在缺氧期间和 2 小时的随访期间收集生命体征。使用二项逻辑回归分析来检查引发头痛、偏头痛、先兆、畏光和畏声的概率。
在 30 名参与者中，24 名（80.0%）出现头痛，19 名（63.3%）出现偏头痛，5 名（16.7%）出现先兆。两名出现先兆的患者在其一生中从未经历过先兆症状。头痛或偏头痛患者的平均心率增加更高。缺氧期间的平均 SpO2 为 83.39%。
缺氧能够独立于任何药物触发偏头痛发作和先兆。
