某些β-内酰胺类抗生素对大肠杆菌中氨基酸转运的抑制作用。
Inhibition of amino acid transport in Escherichia coli by some beta-lactam antibiotics.
作者信息
Anderson S V, Berg C M
出版信息
Antimicrob Agents Chemother. 1977 Jun;11(6):968-73. doi: 10.1128/AAC.11.6.968.
Abstract
Among 10 antibiotics tested, cephaloridine and cephalothin showed the greatest inhibition of proline active transport. Ethylenediaminetetraacetate pretreatment of the cells did not enhance inhibition by any of these 10 antibiotics. The inhibition of active transport of 10 additional amino acids by cephaloridine and cephalothin was studied. Both antibiotics inhibited transport of three amino acids which, like proline, have transport systems resistant to osmotic shock; neither antibiotic inhibited transport of the remaining amino acids, including three with shock-resistant and four with shock-sensitive systems.
摘要
在所测试的10种抗生素中，头孢利定和头孢噻吩对脯氨酸主动转运的抑制作用最强。用乙二胺四乙酸对细胞进行预处理，并不会增强这10种抗生素中的任何一种的抑制作用。研究了头孢利定和头孢噻吩对另外10种氨基酸主动转运的抑制作用。这两种抗生素均抑制了三种氨基酸的转运，这三种氨基酸与脯氨酸一样，具有对渗透休克有抗性的转运系统；这两种抗生素均未抑制其余氨基酸的转运，其余氨基酸包括三种具有抗休克转运系统的氨基酸和四种具有休克敏感转运系统的氨基酸。
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The amino acid pool in Escherichia coli.大肠杆菌中的氨基酸库。
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Studies on amino acid binding proteins of Escherichia coli.大肠杆菌氨基酸结合蛋白的研究。
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Differential recovery of auxotrophs after penicillin enrichment in Escherichia coli.大肠杆菌经青霉素富集后营养缺陷型菌株的差异恢复
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Proline uptake by disrupted membrane preparations from Escherichia coli.大肠杆菌破碎细胞膜制剂对脯氨酸的摄取
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