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在模拟受感染膀胱环境的条件下，β-内酰胺类抗生素对氨苄西林敏感的大肠杆菌的比较性能。

The comparative performance of beta-lactam antibiotics against ampicillin sensitive Escherichia coli in conditions simulating those of the infected urinary bladder.

作者信息

Greenwood D, O'Grady F

出版信息

Br J Exp Pathol. 1974 Jun;55(3):245-50.

PMID:4607731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2072632/
Abstract

The response of an ampicillin sensitive strain of to 6 beta-lactam antibiotics was compared in a mechanical model which simulates the hydrokinetic features of the urinary bladder. The performance of the antibiotics was found to differ in a way that could not be predicted by more conventional techniques. For example, benzylpenicillin was found to be at least as effective as any cephalosporin. Possible reasons for these findings and the relevance of the results to therapeutic practice are discussed.

摘要

在一个模拟膀胱流体动力学特征的力学模型中，比较了氨苄西林敏感菌株对6种β-内酰胺类抗生素的反应。发现这些抗生素的性能差异方式无法通过更传统的技术预测。例如，发现苄青霉素至少与任何头孢菌素一样有效。讨论了这些发现的可能原因以及结果与治疗实践的相关性。

相似文献

1
The comparative performance of beta-lactam antibiotics against ampicillin sensitive Escherichia coli in conditions simulating those of the infected urinary bladder.在模拟受感染膀胱环境的条件下，β-内酰胺类抗生素对氨苄西林敏感的大肠杆菌的比较性能。
Br J Exp Pathol. 1974 Jun;55(3):245-50.
2
Response of ampicillin resistant Escherichia coli to cephalosporins in an in vitro model simulating conditions of bacterial growth in the urinary bladder.在模拟膀胱细菌生长条件的体外模型中，氨苄西林耐药性大肠杆菌对头孢菌素的反应。
Br J Exp Pathol. 1975 Apr;56(2):167-71.
3
The demonstration and significance of synergism between -lactam antibiotics.β-内酰胺类抗生素之间协同作用的论证及意义。
J Med Microbiol. 1971 May;4(2):227-37. doi: 10.1099/00222615-4-2-227.
4
[Transmissible resistance toward polysynthetic penicillins].对多种合成青霉素的可传播耐药性
Antibiotiki. 1971 Jun;16(6):523-5.
5
Combined action of beta-lactum antibiotics against gram-negative bacilli.β-内酰胺类抗生素对革兰氏阴性杆菌的联合作用。
J Hyg Epidemiol Microbiol Immunol. 1973;17(2):129-40.
6
Comparison of the responses of Escherichia coli and proteus mirabilis to seven beta-lactam antibodies.大肠杆菌和奇异变形杆菌对七种β-内酰胺抗体反应的比较。
J Infect Dis. 1973 Aug;128(2):211-22. doi: 10.1093/infdis/128.2.211.
7
In vitro activity against Escherichia coli of CGP 9000, a new oral cephalosporin.新型口服头孢菌素CGP 9000对大肠杆菌的体外活性
J Antibiot (Tokyo). 1978 Jul;31(7):697-702. doi: 10.7164/antibiotics.31.697.
8
Resistance to beta-lactam antibiotics Proteus strains.对β-内酰胺类抗生素的耐药性 变形杆菌菌株。
Acta Microbiol Pol A. 1975;8(3):141-9.
9
[Inhibition by penicillin and cephalosporin analogs of Staphylococcus aureus beta-lactamase using as substrates: benzylpenicillin, ampicillin and carbenicillin].[以苄青霉素、氨苄青霉素和羧苄青霉素为底物时，青霉素和头孢菌素类似物对金黄色葡萄球菌β-内酰胺酶的抑制作用]
Mikrobiologiia. 1974 Sep-Oct;43(5):844-8.
10
[Molecular-biological bases of the mechanism of action of penicillins and cephasporins].[青霉素和头孢菌素作用机制的分子生物学基础]
Pharmazie. 1970 Jan 1;25(1):10-22.

引用本文的文献

1
Resolving Fast, Confined Diffusion in Bacteria with Image Correlation Spectroscopy.用图像相关光谱法解析细菌中的快速、受限扩散
Biophys J. 2016 May 24;110(10):2241-51. doi: 10.1016/j.bpj.2016.04.023.
2
Letter: Co-trimoxazole and cephalexin in urinary tract infection.信函：复方新诺明与头孢氨苄治疗尿路感染
Br Med J. 1976 May 1;1(6017):1073. doi: 10.1136/bmj.1.6017.1073.
3
Activity of cefazolin against dense populations of enterobacteria.头孢唑林对大量肠道杆菌的活性。
Antimicrob Agents Chemother. 1975 Feb;7(2):191-5. doi: 10.1128/AAC.7.2.191.
4
Response of ampicillin resistant Escherichia coli to cephalosporins in an in vitro model simulating conditions of bacterial growth in the urinary bladder.在模拟膀胱细菌生长条件的体外模型中，氨苄西林耐药性大肠杆菌对头孢菌素的反应。
Br J Exp Pathol. 1975 Apr;56(2):167-71.
5
Dual-action cephalosporin utilizing a novel therapeutic principle.采用新型治疗原理的双效头孢菌素。
Antimicrob Agents Chemother. 1976 Aug;10(2):249-52. doi: 10.1128/AAC.10.2.249.
6
Activity and interaction of trimethoprim and sulphamethoxazole against Escherichia coli.甲氧苄啶和磺胺甲恶唑对大肠杆菌的活性及相互作用
J Clin Pathol. 1976 Feb;29(2):162-6. doi: 10.1136/jcp.29.2.162.
7
Use of polyvinylpyrrolidone in the testing of staphylococci for sensitivity to methicillin and cephradine.聚乙烯吡咯烷酮在葡萄球菌对甲氧西林和头孢拉定敏感性测试中的应用。
J Clin Pathol. 1978 May;31(5):434-6. doi: 10.1136/jcp.31.5.434.
8
Factors influencing the response of Escherichia coli to antibiotics in conditions prevailing in the infected urinary bladder.在受感染膀胱中普遍存在的条件下，影响大肠杆菌对抗生素反应的因素。
Br J Exp Pathol. 1976 Jun;57(3):303-9.

本文引用的文献

1
Laoratory appraisal of cephalexin.
Antimicrob Agents Chemother (Bethesda). 1968;8:353-60.
2
A comparative study of eight distinct beta-lactamases synthesized by gram-negative bacteria.对革兰氏阴性菌合成的八种不同β-内酰胺酶的比较研究。
J Gen Microbiol. 1970 Apr;61(1):43-61. doi: 10.1099/00221287-61-1-43.
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Interaction of cephaloridine with penicillinase-producing gram-negative bacteria.
Nature. 1965 Oct 16;208(5007):235-7. doi: 10.1038/208235a0.
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Some relationships between R-factor and chromosomal -lactamase in Gram-negative bacteria.革兰氏阴性菌中R因子与染色体β-内酰胺酶之间的一些关系。
Biochem J. 1971 Jul;123(4):507-12. doi: 10.1042/bj1230507.
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Trimodal response of Escherichia coli and Proteus mirabilis to penicillins.大肠杆菌和奇异变形杆菌对青霉素的三联反应。
Nature. 1970 Oct 31;228(5270):457-8. doi: 10.1038/228457a0.
6
Development and further applications of a simple turbidity cell for continuously monitoring bacterial growth.一种用于连续监测细菌生长的简易比浊计的开发及进一步应用
Phys Med Biol. 1973 Mar;18(2):265-71. doi: 10.1088/0031-9155/18/2/010.
7
Comparison of the responses of Escherichia coli and proteus mirabilis to seven beta-lactam antibodies.大肠杆菌和奇异变形杆菌对七种β-内酰胺抗体反应的比较。
J Infect Dis. 1973 Aug;128(2):211-22. doi: 10.1093/infdis/128.2.211.
8
Treatment of "bacterial cystitis" in fully automatic machanical models simulating conditions of bacterial growth in the urinary bladder.在模拟膀胱细菌生长条件的全自动机械模型中治疗“细菌性膀胱炎”。
Br J Exp Pathol. 1973 Jun;54(3):283-90.
9
The effect of osmolality on the response of Escherichia coli and Proteus mirabilis to penicillins.渗透压摩尔浓度对大肠杆菌和奇异变形杆菌对青霉素反应的影响。
Br J Exp Pathol. 1972 Oct;53(5):457-64.
10
Mucopeptide hydrolases and bacterial "persisters".
Lancet. 1972 Sep 2;2(7775):465-6. doi: 10.1016/s0140-6736(72)91858-2.