Essakalli-Gharbi M, Abbal M, Tkaczuk J, Legrand M F, Adoue D, Ohayon E
Laboratoire Central d'Immunologie, CHU-Toulouse, France.
Pathol Biol (Paris). 1988 Feb;36(2):133-8.
The presence of an IgG oligoclonal pattern was investigated by isoelectric focusing and immuno detection in 151 individuals over 60 years of age. One hundred are individuals with no detectable monoclonal anomaly and among them, 22 exhibit an oligoclonal pattern. The others are 27 patients with a benign and 24 with a malign monoclonal dysglobulinemia, including respectively 9 and 2 oligoclonal patterns. In all groups the oligoclonal pattern is always found among the oldest individuals. The small association found between this special distribution of the IgG and the benign monoclonal dysglobulinemia seems to be most probably in favour of aging. The IgG oligoclonal distribution associated to a monoclonal component would not be a discriminating argument for malignant or benign monoclonal proliferation diagnosis.
通过等电聚焦和免疫检测对151名60岁以上个体的IgG寡克隆模式进行了研究。其中100名个体未检测到单克隆异常，其中22名呈现寡克隆模式。其他个体包括27例良性单克隆丙种球蛋白血症患者和24例恶性单克隆丙种球蛋白血症患者，分别有9例和2例呈现寡克隆模式。在所有组中，寡克隆模式总是在年龄最大的个体中发现。IgG这种特殊分布与良性单克隆丙种球蛋白血症之间的微弱关联似乎最有可能与衰老有关。与单克隆成分相关的IgG寡克隆分布并非恶性或良性单克隆增殖诊断的鉴别依据。
