School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, People's Republic of China.
Technical Platform for the Molecular Biology, Research Core Facility, Southwest Medical University, Luzhou, 646000, People's Republic of China.
World J Microbiol Biotechnol. 2020 Aug 14;36(9):137. doi: 10.1007/s11274-020-02913-3.
Infection rates and mortality associated with the invasive fungi Candida, Aspergillus, and Cryptococcus are increasing rapidly in prevalence. Meanwhile, screening pressure brought about by traditional antifungal drugs has induced an increase in drug resistance of invasive fungi, which creates a great challenge for the preservation of physical health. Development of new drugs and novel strategies are therefore important to meet these growing challenges. Recent studies have confirmed that the dynamic balance of microorganisms in the body is correlated with the occurrence of infectious diseases. This discovery of interactions between bacteria and fungi provides innovative insight for the treatment of invasive fungal infections. However, different invasive fungi and symbiotic bacteria interact with each other through various ways and targets, leading to different effects on their growth, morphology, and virulence. And the mechanism and implication of these interactions remains largely unknown. The present review aims to summarize the research progress into the interaction between invasive fungi and symbiotic bacteria with a focus on the anti-fungal mechanisms of symbiotic bacteria, providing a new strategy against drug-resistant fungal infections.
侵袭性真菌（如念珠菌、曲霉和隐球菌）的感染率和死亡率正在迅速上升。与此同时，传统抗真菌药物的筛选压力导致侵袭性真菌的耐药性增加，这对身体健康的维护带来了巨大挑战。因此，开发新的药物和新的策略对于应对这些日益增长的挑战非常重要。最近的研究证实，体内微生物的动态平衡与传染病的发生有关。这一发现为治疗侵袭性真菌感染提供了细菌和真菌相互作用的新视角。然而，不同的侵袭性真菌和共生细菌通过各种方式和靶点相互作用，对它们的生长、形态和毒力产生不同的影响。而这些相互作用的机制和意义在很大程度上尚不清楚。本综述旨在总结侵袭性真菌与共生细菌相互作用的研究进展，重点关注共生细菌的抗真菌机制，为对抗耐药性真菌感染提供新策略。
