Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Nat Rev Microbiol. 2010 May;8(5):340-9. doi: 10.1038/nrmicro2313. Epub 2010 Mar 29.
Whether it is in the setting of disease or in a healthy state, the human body contains a diverse range of microorganisms, including bacteria and fungi. The interactions between these taxonomically diverse microorganisms are highly dynamic and dependent on a multitude of microorganism and host factors. Human disease can develop from an imbalance between commensal bacteria and fungi or from invasion of particular host niches by opportunistic bacterial and fungal pathogens. This Review describes the clinical and molecular characteristics of bacterial-fungal interactions that are relevant to human disease.
无论是在疾病环境还是健康状态下，人体都含有多种多样的微生物，包括细菌和真菌。这些在分类学上多种多样的微生物之间的相互作用高度动态，取决于众多微生物和宿主因素。人类疾病可能是由共生细菌和真菌之间的失衡引起的，也可能是由机会性细菌和真菌病原体侵袭特定宿主小生境引起的。本综述描述了与人类疾病相关的细菌-真菌相互作用的临床和分子特征。
