Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA.
Department of Animal Sciences, The Ohio State University, Columbus, Ohio, USA.
J Vet Intern Med. 2020 Sep;34(5):2012-2020. doi: 10.1111/jvim.15866. Epub 2020 Aug 14.
Osseous-associated cervical spondylomyelopathy (OA-CSM) is a complex disorder with limited long-term survival. The longitudinal progression is currently unknown.
To describe changes on magnetic resonance imaging (MRI) over a 2-year minimum period. We hypothesized that spinal lesions would progress in the majority of dogs.
Eleven dogs previously diagnosed with OA-CSM were prospectively studied. Nine dogs were treated medically, whereas 2 were treated surgically.
Clinical and MRI follow-up were performed with a median time between MRI studies of 30 months (range, 24-54). Morphologic assessment evaluated vertebral canal stenosis, spinal cord compression, foraminal stenosis, and articular processes, among other variables. Morphometric assessment included vertebral canal area, spinal cord area, area of the articular processes, and foraminal height.
On follow-up MRI, the most affected site at the initial examination in medically treated dogs had progressed in 4 of 9 dogs, improved in 4, and was unchanged in 3. Clinically, all dogs except 2 medically treated dogs were unchanged to improve at follow-up. Initially, 50 of 60 (83.3%) intervertebral spaces had vertebral canal stenosis, whereas in the follow-up MRI 82.3% did. Of the sites with stenosis, 45.7% were unchanged, 18.6% improved, and 38.9% worsened. Morphometry identified significant decreases in vertebral canal and spinal cord areas at C4-C5 through C6-C7, and significant progression of articular process irregularities at C3-C4 and C6-C7.
This long-term follow-up study of dogs with OA-CSM did not identify clinical or MRI progression of lesions in the majority of dogs.
骨相关型颈椎病（OA-CSM）是一种复杂的疾病，长期存活率有限。目前尚不清楚其纵向进展情况。
描述至少 2 年的时间内磁共振成像（MRI）的变化。我们假设大多数犬的脊柱病变会进展。
11 只先前被诊断为 OA-CSM 的犬进行了前瞻性研究。9 只犬接受了药物治疗，2 只接受了手术治疗。
对临床和 MRI 进行了随访，两次 MRI 检查的中位数时间间隔为 30 个月（范围，24-54）。形态评估评估了椎管狭窄、脊髓压迫、椎间孔狭窄和关节突等变量。形态计量评估包括椎管面积、脊髓面积、关节突面积和椎间孔高度。
在随访 MRI 上，在药物治疗犬的初始检查中最受影响的部位在 9 只犬中有 4 只进展，4 只改善，3 只不变。临床上，除了 2 只药物治疗犬外，所有犬在随访时都没有变化或改善。最初，60 个椎间盘中有 50 个（83.3%）存在椎管狭窄，而在随访 MRI 中有 82.3%存在狭窄。在狭窄部位中，45.7%不变，18.6%改善，38.9%恶化。形态计量学发现 C4-C5 至 C6-C7 的椎管和脊髓面积显著减小，C3-C4 和 C6-C7 的关节突不规则显著进展。
这项对 OA-CSM 犬的长期随访研究并未发现大多数犬的病变在临床上或 MRI 上进展。
