Hepatology Unit, Department of Infectious Diseases, Guangzhou Women and Children's Medical Center, Guangzhou Medical University.
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Eur J Gastroenterol Hepatol. 2021 Nov 1;33(11):1394-1399. doi: 10.1097/MEG.0000000000001874.
We aimed to establish the basal reference levels of liver stiffness and accumulated fat in healthy Chinese children.
To obtain the liver stiffness measurement (LSM) and the fat attenuation parameter (FAP) levels, the transient elastography (FibroTouch) was used in pediatric patients aged 0 to 18 years. The patients were divided into groups as follows: newborns/infants (0-2 years), preschool children (3-5 years), elementary school children (6-11 years), and adolescents/teenagers (12-18 years). The weight, height and fasting liver function tests were performed. FibroTouch and abdominal ultrasonography were performed.
The livers of 521 out of 1362 children (329 male; median age, 4.6 years; age range 0.2-17.6 years) were examined with the FibroTouch. The LSM reference range was 1.5-5.9 kPa, and the FAP reference range was 159.6-217.1 dB/m in healthy children from 0 to 18 years of age. The median LSM value was higher in males than that in females (3.5 vs. 3.2 kPa, respectively; P = 0.01).
For healthy children from 0 to 18 years in southern China, the LSM reference range was 1.5-5.9 kPa, and the FAP reference range was 159.6-217.1 dB/m. The LSM values were age-dependent in children from 3 to 18 years old, and the FAP values were age-independent in children from 0 to18 years old.
建立健康中国儿童肝脏硬度和脂肪衰减参数的基础参考值。
使用瞬时弹性成像（FibroTouch）对 0 至 18 岁的儿科患者进行肝脏硬度测量（LSM）和脂肪衰减参数（FAP）检测。患者分为新生儿/婴儿组（0-2 岁）、学龄前儿童组（3-5 岁）、小学生组（6-11 岁）和青少年/青少年组（12-18 岁）。检测体重、身高和空腹肝功能。进行 FibroTouch 和腹部超声检查。
对 1362 名儿童中的 521 名（329 名男性；中位年龄 4.6 岁；年龄范围 0.2-17.6 岁）的肝脏进行了 FibroTouch 检查。健康儿童的 LSM 参考范围为 1.5-5.9 kPa，FAP 参考范围为 159.6-217.1 dB/m，年龄为 0-18 岁。男性的 LSM 中位数高于女性（分别为 3.5 和 3.2 kPa，P=0.01）。
对于来自中国南方 0 至 18 岁的健康儿童，LSM 的参考范围为 1.5-5.9 kPa，FAP 的参考范围为 159.6-217.1 dB/m。3 至 18 岁儿童的 LSM 值随年龄增长而变化，0 至 18 岁儿童的 FAP 值与年龄无关。
