Ramírez-Vélez Robinson, García-Hermoso Antonio, Correa-Rodríguez María, Izquierdo Mikel
Department of Health Sciences, Public University of Navarra, Navarrabiomed-IdiSNA, Complejo Hospitalario de Navarra (CHN), Pamplona, Spain.
CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Pediatr Res. 2022 Mar;91(4):912-920. doi: 10.1038/s41390-021-01441-6. Epub 2021 Apr 12.
We aimed to determine the reference values to define an age-specific normal range of controlled attenuation parameter (CAP, a measure of liver steatosis) and liver stiffness measurement (LSM) values assessed by ultrasound-based transient elastography in adolescents without underlying liver disease.
A total of 462 participants were included in this cross-sectional study using data from NHANES 2017-2018. LSM and CAP were carried out using the FibroScan® M-probe. Anthropometric, metabolic and hematological parameters were measured.
The median CAP was 199.0 dB/m (150.0-245.0 dB/m, 10th to 90th percentiles) and the median LSM was 4.7 kPa (3.4-6.3 kPa, 10th to 90th percentiles) for ages 12-19.9 years. Regression analyses show that the CAP and LSM were not positively correlated with age (boys CAP R = 0.001, p = 0.576 and LSM R = 0.012, p = 0.096; girls CAP R = 0.011, p = 0.113 and LSM R = 0.006, p = 0.236). Finally, CAP was positively associated with LSM in girls (β = 0.189, p = 0.005) but not in boys (β = -0.083, p = 0.202).
The reference values indicated here for LSM and CAP will help in the screening of adolescents between ages 12 and 19.9 years and might serve as a useful method for identifying those youth at high risk of nonalcoholic fatty liver disease.
The reference values indicated in this study for liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) will help in the screening of adolescents between ages 12 and 19.9 years in clinical practice. The cutoffs of LSM and CAP might serve as a useful method for identifying those youth at high risk of nonalcoholic fatty liver disease.
我们旨在确定参考值，以定义无潜在肝脏疾病的青少年通过基于超声的瞬时弹性成像评估的控制衰减参数（CAP，肝脏脂肪变性的一种测量指标）和肝脏硬度测量（LSM）值的特定年龄正常范围。
本横断面研究使用2017 - 2018年美国国家健康与营养检查调查（NHANES）的数据，共纳入462名参与者。使用FibroScan® M探头进行LSM和CAP检测。测量人体测量学、代谢和血液学参数。
12至19.9岁人群的CAP中位数为199.0 dB/m（第10至90百分位数为150.0 - 245.0 dB/m），LSM中位数为4.7 kPa（第10至90百分位数为3.4 - 6.3 kPa）。回归分析表明，CAP和LSM与年龄无正相关（男孩CAP：R = 0.001，p = 0.576；LSM：R = 0.012，p = 0.096；女孩CAP：R = 0.011，p = 0.113；LSM：R = 0.006，p = 0.236）。最后，CAP在女孩中与LSM呈正相关（β = 0.189，p = 0.005），但在男孩中无相关性（β = -0.083，p = 0.202）。
此处给出的LSM和CAP参考值将有助于筛查12至19.9岁的青少年，可能作为识别非酒精性脂肪性肝病高风险青年的有用方法。
本研究中给出的肝脏硬度测量（LSM）和控制衰减参数（CAP）参考值将有助于临床实践中筛查12至19.9岁的青少年。LSM和CAP的临界值可能作为识别非酒精性脂肪性肝病高风险青年的有用方法。
