O'Leary Christine K, Jones Cheryl, Bryant Penelope A, Abo Yara-Natalie, Osowicki Joshua, Gwee Amanda
From the Department of General Medicine, The Royal Children's Hospital, Victoria, Australia.
Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, NSW, Australia.
Pediatr Infect Dis J. 2020 Sep;39(9):830-832. doi: 10.1097/INF.0000000000002692.
Current guidelines for severe herpes simplex virus infection recommend 21 days of intravenous therapy. The thrice-daily administration of intravenous acyclovir makes it challenging to deliver as outpatient therapy. We describe 2 cases with confirmed or presumed neonatal herpes simplex virus encephalitis treated with acyclovir administered as a continuous-infusion at home and review the pharmacologic and clinical evidence for continuous infusions of acyclovir.
目前针对严重单纯疱疹病毒感染的指南推荐进行21天的静脉治疗。静脉注射阿昔洛韦每日三次给药，使得作为门诊治疗实施起来具有挑战性。我们描述了2例确诊或疑似新生儿单纯疱疹病毒性脑炎的病例，这些病例在家中接受了阿昔洛韦持续静脉输注治疗，并回顾了阿昔洛韦持续静脉输注的药理学和临床证据。
