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CD19 antibody-drug conjugate therapy in DLBCL does not preclude subsequent responses to CD19-directed CAR T-cell therapy.

作者信息

Thapa Bicky, Caimi Paolo F, Ardeshna Kirit M, Solh Melhem, Carlo-Stella Carmelo, Kahl Brad S, Hamadani Mehdi

机构信息

BMT & Cellular Therapy Program, Medical College of Wisconsin, Milwaukee, WI.

University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH.

出版信息

Blood Adv. 2020 Aug 25;4(16):3850-3852. doi: 10.1182/bloodadvances.2020002587.

DOI:10.1182/bloodadvances.2020002587
PMID:32797191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7448593/
Abstract
摘要

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A Phase I Study of ADCT-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma.ADCT-402（Loncastuximab Tesirine）治疗复发/难治性 B 细胞非霍奇金淋巴瘤的 I 期研究，Loncastuximab Tesirine 是一种新型的吡咯苯并二氮杂卓类抗体药物偶联物。
Clin Cancer Res. 2019 Dec 1;25(23):6986-6994. doi: 10.1158/1078-0432.CCR-19-0711. Epub 2019 Nov 4.
2
Use of Chimeric Antigen Receptor T Cell Therapy in Clinical Practice for Relapsed/Refractory Aggressive B Cell Non-Hodgkin Lymphoma: An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy.嵌合抗原受体 T 细胞疗法在复发/难治性侵袭性 B 细胞非霍奇金淋巴瘤临床实践中的应用：来自美国移植和细胞治疗学会的专家小组意见。
Biol Blood Marrow Transplant. 2019 Dec;25(12):2305-2321. doi: 10.1016/j.bbmt.2019.08.015. Epub 2019 Aug 22.
3
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.Tisagenlecleucel 治疗成人复发或难治性弥漫性大 B 细胞淋巴瘤。
N Engl J Med. 2019 Jan 3;380(1):45-56. doi: 10.1056/NEJMoa1804980. Epub 2018 Dec 1.
4
Management of relapsed/refractory DLBCL.复发/难治性弥漫性大B细胞淋巴瘤的管理
Best Pract Res Clin Haematol. 2018 Sep;31(3):209-216. doi: 10.1016/j.beha.2018.07.014. Epub 2018 Jul 23.
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Phase IIa study of the CD19 antibody MOR208 in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma.CD19 抗体 MOR208 治疗复发或难治性 B 细胞非霍奇金淋巴瘤的 IIa 期研究。
Ann Oncol. 2018 May 1;29(5):1266-1272. doi: 10.1093/annonc/mdy056.
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ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies.ADCT-402，一种含有吡咯并苯二氮䓬二聚体的抗体药物偶联物，针对表达 CD19 的恶性肿瘤。
Blood. 2018 Mar 8;131(10):1094-1105. doi: 10.1182/blood-2017-10-813493. Epub 2018 Jan 3.
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N Engl J Med. 2017 Dec 28;377(26):2531-2544. doi: 10.1056/NEJMoa1707447. Epub 2017 Dec 10.
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Early failure of frontline rituximab-containing chemo-immunotherapy in diffuse large B cell lymphoma does not predict futility of autologous hematopoietic cell transplantation.弥漫性大B细胞淋巴瘤一线含利妥昔单抗的化疗免疫疗法早期失败并不能预测自体造血细胞移植无效。
Biol Blood Marrow Transplant. 2014 Nov;20(11):1729-36. doi: 10.1016/j.bbmt.2014.06.036. Epub 2014 Jul 5.
9
Current concepts in the diagnosis and management of cytokine release syndrome.细胞因子释放综合征的诊断和治疗的当前概念。
Blood. 2014 Jul 10;124(2):188-95. doi: 10.1182/blood-2014-05-552729. Epub 2014 May 29.
10
CD19 antigen in leukemia and lymphoma diagnosis and immunotherapy.CD19抗原在白血病和淋巴瘤的诊断及免疫治疗中的应用
Leuk Lymphoma. 1995 Aug;18(5-6):385-97. doi: 10.3109/10428199509059636.