Yonemoto R H, Schick P, Albano W, Fujisawa T, Waldman S H
Arch Surg. 1977 Aug;112(8):991-6. doi: 10.1001/archsurg.1977.01370080089015.
We set out to answer the question, "Is the effect of adrenalectomy associated with or mediated through the immune response?" Eleven patients were studied preoperatively and postoperatively by in vitro immunologic tests. The assay system used included absolute T cell counts, phytohemagglutinin (PHA) blastogenesis, leukocyte adherence inhibition (LAI) after contact with 3M potassium chloride breast antigens, and blocking as measured in the blastogenesis and LAI assays. Good correlation was found between favorable clinical response to adrenalectomy and a rise in the number of absolute T cells, an increase in LAI positivity, and a decrease in blocking as measured by LAI blocking assay, but no correlation was seen in PHA blastogenesis assays. The association of clinical objective responses and improved immune responses is of significance.
“肾上腺切除术的效果是与免疫反应相关还是通过免疫反应介导？”术前和术后通过体外免疫测试对11名患者进行了研究。所使用的检测系统包括绝对T细胞计数、植物血凝素（PHA）刺激增殖、接触3M氯化钾乳腺抗原后的白细胞黏附抑制（LAI）以及在刺激增殖和LAI检测中测量的封闭作用。肾上腺切除术的良好临床反应与绝对T细胞数量增加、LAI阳性率升高以及通过LAI封闭检测测量的封闭作用降低之间存在良好的相关性，但在PHA刺激增殖检测中未发现相关性。临床客观反应与免疫反应改善之间的关联具有重要意义。
