Catalona W J, Tarpley J L, Potvin C, Chretien P B
Clin Exp Immunol. 1975 Feb;19(2):327-33.
Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PHA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded statistically significant positive correlations between the DNCB and PHA assays in twenty-one of twenty-eight instances, the DNCB and E rosette assays in thirteen of sixteen instances, the PHA and E rosette assays in twenty-eight of thirty-six instances, and among the DNCB, PHA and E rosette assays in ten of fourteen instances. The results suggest that both PHA-stimulated lymphocyte blastogenesis and peripheral blood E rosette-forming lymphocyte levels provide meaningful in vitro correlates of cell-mediated immunity.
在一项针对52例泌尿生殖系统恶性肿瘤患者的研究中，运用三种检测方法来监测胸腺依赖性免疫系统（对二硝基氯苯的迟发型皮肤超敏反应、PHA诱导的淋巴细胞增殖以及外周血E花环形成淋巴细胞计数），结果显示，在28例中的21例里，DNCB检测与PHA检测之间存在具有统计学意义的正相关；在16例中的13例里，DNCB检测与E花环检测之间存在正相关；在36例中的28例里，PHA检测与E花环检测之间存在正相关；在14例中的10例里，DNCB、PHA和E花环检测之间存在正相关。结果表明，PHA刺激的淋巴细胞增殖以及外周血E花环形成淋巴细胞水平均为细胞介导免疫提供了有意义的体外相关指标。
