Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Phytother Res. 2020 Dec;34(12):3367-3378. doi: 10.1002/ptr.6791. Epub 2020 Aug 15.
Nonalcoholic fatty liver disease (NAFLD) is characterized by oxidative stress and inflammation in the hepatocytes. Saffron and its constituents are reported to have several properties such as anti-inflammatory and anti-diabetic effects.
In a randomized double-blind placebo-controlled trial with two parallel groups including 76 eligible men and female patients with NAFLD aged 18-65, recruited from Hazrat Rasul Akram Hospital in Tehran, Iran. NAFLD was defined by a Gastroenterologist based on the American Gastrointestinal and Liver Association standards. Participants were randomly assigned to two groups receiving daily supplementation of either one tablet of 100 mg saffron (n = 38) or one placebo (n = 38) for 12 weeks. The primary outcome was high sensitive C-reactive protein (hs-CRP) and secondary outcomes were alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor alpha (TNF-α), malondialdehyde (MDA), total anti-oxidant capacity (TAC), leptin, adiponectin, anthropometric, and body composition Both groups were assigned similar diet and physical activity.
In the treatment group, significant decreases in hs-CRP (-1.80 ng/ml, 95% CI = -2.97, -0.63, p = .032), leptin (-0.27 ng/ml, 95% CI = -0.65, -0.10, p = .040), MDA (-1.01 ng/ml, 95% CI = -1.89, -0.14, p = .023) and significant increase in TAC (0.34 μmol/L, 95% CI = 0.08, 0.61, p = .011) were observed compared to the placebo group. However, there were no significant changes in serum alanine aminotransferase, AST, TNF-α, body composition, and anthropometric indexes (p > .05).
In the present study, 12 weeks of 100 mg of saffron supplementation indicated beneficial effects on serum levels of some inflammatory, oxidative stress, and adipokines biomarkers but it had no significant effect on serum concentrations of liver enzymes, anthropometric, and body composition measurements.
非酒精性脂肪性肝病（NAFLD）的特征是肝细胞中的氧化应激和炎症。藏红花及其成分据称具有多种特性，如抗炎和抗糖尿病作用。
在一项随机、双盲、安慰剂对照的临床试验中，包括 76 名年龄在 18-65 岁之间的伊朗德黑兰哈扎拉特·拉苏尔·阿克拉姆医院的符合条件的男性和女性 NAFLD 患者，分为两组。NAFLD 是由胃肠病学家根据美国胃肠病学和肝脏协会标准定义的。参与者被随机分配到两组，每天分别补充 1 片 100 毫克藏红花（n = 38）或 1 片安慰剂（n = 38），持续 12 周。主要结局是高敏 C 反应蛋白（hs-CRP），次要结局是丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、肿瘤坏死因子-α（TNF-α）、丙二醛（MDA）、总抗氧化能力（TAC）、瘦素、脂联素、人体测量和身体成分。两组均给予相似的饮食和体育活动。
在治疗组中，hs-CRP 显著降低（-1.80ng/ml，95%CI=-2.97，-0.63，p=0.032），瘦素降低（-0.27ng/ml，95%CI=-0.65，-0.10，p=0.040），MDA 降低（-1.01ng/ml，95%CI=-1.89，-0.14，p=0.023），TAC 显著升高（0.34μmol/L，95%CI=0.08，0.61，p=0.011）与安慰剂组相比。然而，血清丙氨酸氨基转移酶、AST、TNF-α、身体成分和人体测量指数无显著变化（p>.05）。
在本研究中，12 周 100 毫克藏红花补充剂对一些炎症、氧化应激和脂肪因子生物标志物的血清水平有有益的影响，但对血清肝酶、人体测量和身体成分测量无显著影响。
