藏红花（Crocus sativus L.）联合常规训练对 2 型糖尿病肥胖男性体成分、血糖状态和炎症标志物的影响：一项随机双盲临床试验。

The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized double-blind clinical trial.

机构信息

Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.

Department of Exercise Physiology, University of Tehran, Tehran, Iran.

出版信息

Br J Clin Pharmacol. 2022 Jul;88(7):3256-3271. doi: 10.1111/bcp.15222. Epub 2022 Feb 18.

DOI:10.1111/bcp.15222

PMID:35001410

Abstract

AIMS

Chronic inflammation is one of the major challenges in the management of obesity and type 2 diabetes mellitus (T2DM). Our primary aim was to assess the anti-inflammatory effects of Saffron (Crocus sativus L.) supplementation and concurrent training in obese men with T2DM.

METHODS

Sixty obese men with T2DM (age = 39 ± 5 years; body mass = 93.9 ± 6 kg) were randomly assigned to four groups; concurrent training + placebo (CT; n = 15), saffron supplementation (S; n = 15), concurrent training + saffron supplementation (CTS; n = 15), or control (CON; n = 15). The participants in the CT group performed concurrent training (resistance + aerobic) three times per week for 12 weeks and received daily one pill of placebo (maltodextrin); the participants in the S group supplemented with one pill of 100 mg of saffron daily, and the participants in the CTS group participated in both saffron and training intervention while CON group continued regular lifestyle (no training and no supplementation). Inflammatory markers, body composition (evaluated by a multi-frequency bioelectrical impedance device; Jawon X-Contact 356), and metabolic profile were evaluated before and after interventions.

RESULTS

All three interventions significantly (P < .05) decreased TNF-α (CT = -4.22, S = -1.91, CTS = -9.69 pg/mL), hs-CRP (CT = -0.13, S = -0.1, CTS = -0.32 ng/mL), IL-6 (CT = -6.84, S = -6.36, CTS = -13.55 pg/mL), IL-1β (CT = -8.85, S = -6.46, CTS = -19.8 pg/mL), FBG (CT = -6.97, S = -2.45, CTS = -13.86 mg/dL), insulin (CT = -0.13, S = -0.03, CTS = -0.21 mU/L), HOMA-IR (CT = -0.12, S = -0.04, CTS = -0.21), HbA1c (CT = -0.17, S = -0.11, CTS = -0.26%), and increased IL-10 (CT = 1.09, S = 0.53, CTS = 2.27 pg/mL) concentrations. There was a positive correlation between changes in BFP with hs-CRP, IL-6, IL-1β and TNF-α, and IL-10 concentrations across the intervention groups. Additionally, significant differences were observed between the changes for all variables in the CTS group compared to CT, S and CON groups (P < .05).

CONCLUSION

It seems that an interaction of saffron supplementation and concurrent training has more efficient effects on anti-inflammatory status compared to saffron supplementation or concurrent training alone.

摘要

目的

慢性炎症是肥胖和 2 型糖尿病（T2DM）管理中的主要挑战之一。我们的主要目的是评估藏红花（Crocus sativus L.）补充剂和同时训练对肥胖的 2 型糖尿病男性的抗炎作用。

方法

60 名肥胖的 2 型糖尿病男性（年龄=39±5 岁；体重=93.9±6kg）被随机分为四组；同时训练+安慰剂（CT；n=15）、藏红花补充剂（S；n=15）、同时训练+藏红花补充剂（CTS；n=15）或对照组（CON；n=15）。CT 组的参与者每周进行三次同时训练（阻力+有氧运动），持续 12 周，并每天服用一片安慰剂（麦芽糊精）；S 组每天补充 100mg 藏红花，CTS 组在接受藏红花和训练干预的同时参与，而 CON 组继续常规生活方式（无训练和无补充）。在干预前后评估炎症标志物、身体成分（使用 Jawon X-Contact 356 多频生物电阻抗仪评估）和代谢谱。

结果

所有三种干预措施均显著（P<0.05）降低 TNF-α（CT=-4.22，S=-1.91，CTS=-9.69pg/mL）、hs-CRP（CT=-0.13，S=-0.1，CTS=-0.32ng/mL）、IL-6（CT=-6.84，S=-6.36，CTS=-13.55pg/mL）、IL-1β（CT=-8.85，S=-6.46，CTS=-19.8pg/mL）、FBG（CT=-6.97，S=-2.45，CTS=-13.86mg/dL）、胰岛素（CT=-0.13，S=-0.03，CTS=-0.21mU/L）、HOMA-IR（CT=-0.12，S=-0.04，CTS=-0.21）、HbA1c（CT=-0.17，S=-0.11，CTS=-0.26%），并增加了 IL-10（CT=1.09，S=0.53，CTS=2.27pg/mL）浓度。在干预组中，BFP 的变化与 hs-CRP、IL-6、IL-1β和 TNF-α以及 IL-10 浓度之间存在正相关。此外，与 CT、S 和 CON 组相比，CTS 组的所有变量变化之间存在显著差异（P<0.05）。