Departamento de Anatomía y Biología Celular and IDIVAL, Universidad de Cantabria, Santander, Spain.
Dev Dyn. 2021 Sep;250(9):1236-1247. doi: 10.1002/dvdy.237. Epub 2020 Sep 2.
Our aim is to critically review current knowledge of the function and regulation of cell death in the developing limb. We provide a detailed, but short, overview of the areas of cell death observed in the developing limb, establishing their function in morphogenesis and structural development of limb tissues. We will examine the functions of this process in the formation and growth of the limb primordia, formation of cartilaginous skeleton, formation of synovial joints, and establishment of muscle bellies, tendons, and entheses. We will analyze the plasticity of the cell death program by focusing on the developmental potential of progenitors prior to death. Considering the prolonged plasticity of progenitors to escape from the death process, we will discuss a new biological perspective that explains cell death: this process, rather than secondary to a specific genetic program, is a consequence of the tissue building strategy employed by the embryo based on the formation of scaffolds that disintegrate once their associated neighboring structures differentiate.
我们的目的是批判性地回顾目前关于细胞死亡在发育肢体中的功能和调节的知识。我们提供了一个详细但简短的综述，介绍了在发育肢体中观察到的细胞死亡区域，确定了它们在肢体组织形态发生和结构发育中的功能。我们将研究这个过程在肢体原基形成和生长、软骨骨骼形成、滑膜关节形成以及肌肉鞘、肌腱和附着点形成中的功能。我们将通过关注死亡前祖细胞的发育潜力来分析细胞死亡程序的可塑性。考虑到祖细胞逃避死亡过程的长期可塑性，我们将讨论一个新的生物学观点，即解释细胞死亡的观点：这个过程不是特定遗传程序的次要结果，而是胚胎基于构建支架的组织构建策略的结果，一旦相关的相邻结构分化，这些支架就会解体。
