Li Qing-Fen, Zhang Qi-Ke, Wei Xiao-Fang, Feng You-Fan
Department of Hematology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu Province, China.
Department of Hematology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu Province, China,E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Aug;28(4):1261-1266. doi: 10.19746/j.cnki.issn.1009-2137.2020.04.030.
To explore the correlation of body mass index (BMI), ABO blood group with multiple myeloma (MM).
70 MM patients (MM group) and 10 healthy people (control group) were selected in the same period, the BMI of patients was calculated according to the height and weight, and the differences of BMI in 2 groups was compared. The distribution of age, sex, albumin (Alb), serum creatinine (Cr), hemoglobin (Hb) and red blood cell (RBC) in the two groups were analyzed. Differences in red blood cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), disease stage and lactate dehydrogenase (LDH) level, survival rate of MM patients with different BMI values and blood group were compared between two groups, and the differences in follow-up outcomes of MM patients were analyzed by univariate and multivariate logistic regression analysis.
BMI level of MM patients was higher than that of control group (t=2.706, P＜0.01), but the difference of blood group was not significant (P＞0.05); The NLR value in obese patients was higher than that in non-obese patients, the staging was later and the Alb level was lower in obese patients than those in non-obese patients. the differences were statistically significant between obese patients and non-obese patients (P＜0.05). Univariate and multivariate analysis showed that BMI, Alb and LDH level could influence the follow-up outcome of MM patients, the patients with elevated BMI and LDH level had worse prognosis, while patients with elevated Alb had better prognosis. which means that all the three factors are independent factors affecting the prognosis of MM patrents.
Increased BMI in MM patients can affect the outcome of follow-up, which is an independent influencing factor.
探讨体重指数（BMI）、ABO血型与多发性骨髓瘤（MM）的相关性。
同期选取70例MM患者（MM组）和10例健康人（对照组），根据身高和体重计算患者的BMI，并比较两组BMI的差异。分析两组年龄、性别、白蛋白（Alb）、血清肌酐（Cr）、血红蛋白（Hb）和红细胞（RBC）的分布情况。比较两组不同BMI值和血型的MM患者红细胞分布宽度（RDW）、中性粒细胞/淋巴细胞比值（NLR）、疾病分期和乳酸脱氢酶（LDH）水平、生存率的差异，并通过单因素和多因素逻辑回归分析MM患者随访结局的差异。
MM患者的BMI水平高于对照组（t=2.706，P＜0.01），但血型差异无统计学意义（P＞0.05）；肥胖患者的NLR值高于非肥胖患者，肥胖患者的分期较晚且Alb水平低于非肥胖患者。肥胖患者与非肥胖患者之间差异有统计学意义（P＜0.05）。单因素和多因素分析显示，BMI、Alb和LDH水平可影响MM患者的随访结局，BMI和LDH水平升高的患者预后较差，而Alb升高的患者预后较好。这意味着这三个因素都是影响MM患者预后的独立因素。
MM患者BMI升高可影响随访结局，是独立的影响因素。
