Sun Yan-Qing, Li Qing-Fen, Zhang Qi-Ke, Wei Xiao-Fang, Feng You-Fan
Department of Hematology, Gansu Provincial People＇s Hospital, Lanzhou 730000, Gansu Province, China.
Department of Hematology, Gansu Provincial People＇s Hospital, Lanzhou 730000, Gansu Province, China,E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Apr;27(2):489-493. doi: 10.19746/j.cnki.issn.1009-2137.2019.02.029.
To study the value of neutrophil/lymphocyte ratio (NLR) in the evaluation of prognosis of patients with multiple myeloma (MM).
NLR was calculated on the basis of the blood routine examination results of 65 patients with primary MM (MM group) and 83 persons receiving physical examination as control group, and the difference in 2 group was compared; moreover according to the median as threshold, the patients were divided into low NLR group (NLR＜2.34) and high NLR group (NLR≥2.34); the differences of age, sex, serum calcium β (Ca), microglobulin (β-MG), albumin (Alb), serum creatinine (Cr), hemoglobin (Hb), red blood cell distribution width (RDW) and lactate dehydrogenase (LDH) in 2 group were analyzed, and the survival rate was compared between the high and low-NLR group.
the NLR of MM patients was statistically significantly higher than that of the control group (z=-2.415, P＜0.05). Compared with the low NLR group, the β-MG and Cr levels of patients in the high NLR group seemed higher, but the difference was not statistically significant. The single-factor analysis showed that NLR, β-MG and Alb levels were risk factors for the prognosis of MM patients, and the multi-factor analysis showed that NLR and Alb level were independent risk factors influencing the prognosis of MM patients.
NLR elevation in patients with primary diagnosis of MM indicates a poor prognosis, which is an independent risk factor affecting the prognosis.
探讨中性粒细胞/淋巴细胞比值（NLR）在评估多发性骨髓瘤（MM）患者预后中的价值。
根据65例原发性MM患者（MM组）的血常规检查结果计算NLR，并以83例体检者作为对照组，比较两组差异；此外，以中位数为界值，将患者分为低NLR组（NLR＜2.34）和高NLR组（NLR≥2.34）；分析两组患者的年龄、性别、血清钙β（Ca）、微球蛋白（β-MG）、白蛋白（Alb）、血清肌酐（Cr）、血红蛋白（Hb）、红细胞分布宽度（RDW）和乳酸脱氢酶（LDH）的差异，并比较高NLR组和低NLR组的生存率。
MM患者的NLR显著高于对照组（z=-2.415，P＜0.05）。与低NLR组相比，高NLR组患者的β-MG和Cr水平似乎更高，但差异无统计学意义。单因素分析显示，NLR、β-MG和Alb水平是MM患者预后的危险因素，多因素分析显示，NLR和Alb水平是影响MM患者预后的独立危险因素。
初诊MM患者NLR升高提示预后不良，是影响预后的独立危险因素。
