Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, China; National Centre for International Research of Low-Carbon and Green Buildings (Ministry of Science and Technology), Chongqing University, Chongqing 400045, China.
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China.
Environ Toxicol Pharmacol. 2020 Nov;80:103469. doi: 10.1016/j.etap.2020.103469. Epub 2020 Aug 13.
Studies have indicated that formaldehyde and low temperature are considered to be the factors associated with several respiratory diseases. However, the effect of co-exposure to formaldehyde and low temperature on allergic asthma, and the potential mechanisms, are unknown. In this study, an allergic asthma mouse model was built and mice were exposed to 0.8 mg/m formaldehyde and/or subjected to low temperatures of 16 °C. The data showed that exposure to either low temperature or formaldehyde did not induce a significant aggravation on allergic asthma. However, simultaneous exposure to formaldehyde and low temperature was shown to aggravate mucus hypersecretion and inflammation in the lung, lead to an exacerbation of allergic asthma. After blocking the TRPM8 and TRPA1 ion channels, the levels of inflammatory factors reduced. These results demonstrated that co-exposure to formaldehyde and low temperature exacerbate allergic asthma, and that TRPM8 and TRPA1 are involved in this process.
研究表明，甲醛和低温被认为是与多种呼吸道疾病相关的因素。然而，甲醛和低温共同暴露对过敏性哮喘的影响及其潜在机制尚不清楚。在这项研究中，构建了过敏性哮喘小鼠模型，并使小鼠暴露于 0.8mg/m3 的甲醛和/或 16°C 的低温中。结果表明，暴露于低温或甲醛均不会显著加重过敏性哮喘。然而，甲醛和低温同时暴露会加重肺部黏液分泌过度和炎症，导致过敏性哮喘恶化。阻断 TRPM8 和 TRPA1 离子通道后，炎症因子水平降低。这些结果表明，甲醛和低温共同暴露会加重过敏性哮喘，而 TRPM8 和 TRPA1 参与了这一过程。
