Department of Ophthalmology, Rio de Janeiro State University, Rio de Janeiro, Brazil,
Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
Ophthalmologica. 2020;243(6):471-478. doi: 10.1159/000510879. Epub 2020 Aug 14.
This study examined the relationship between proliferative diabetic retinopathy (PDR) and serum levels of C-reactive protein, VEGF, TNF-α, and IL-6 inflammatory biomarkers, related to the pathophysiology of diabetic retinopathy.
This cross-sectional, case control study comprised 240 patients with type 1 diabetes (80 cases with PDR and 160 controls without diabetic retinopathy) who were matched for gender and duration of diabetes.
C-reactive protein was the only inflammatory biomarker that was positively related to PDR (OR 1.96; 95% CI 1.01-3.78, p = 0.0045). We also noted an association between high glycated hemoglobin levels, the use of angiotensin-converting enzyme inhibitor, low glomerular filtration rate, and PDR.
Patients with higher levels of C-reactive protein are more likely to present with PDR. We did not find a link between serum levels of VEGF, TNF-α, or IL-6 and PDR. The function of inflammatory biomarkers in PDR must be addressed in further studies.
本研究探讨了增殖性糖尿病视网膜病变（PDR）与血清 C 反应蛋白、VEGF、TNF-α和 IL-6 炎症生物标志物之间的关系，这些标志物与糖尿病视网膜病变的病理生理学有关。
本横断面病例对照研究包括 240 例 1 型糖尿病患者（80 例 PDR 患者和 160 例无糖尿病视网膜病变的对照组），这些患者在性别和糖尿病病程上相匹配。
C 反应蛋白是唯一与 PDR 呈正相关的炎症生物标志物（OR 1.96；95%CI 1.01-3.78，p=0.0045）。我们还注意到糖化血红蛋白水平高、使用血管紧张素转换酶抑制剂、肾小球滤过率低与 PDR 之间存在关联。
C 反应蛋白水平较高的患者更有可能出现 PDR。我们没有发现血清 VEGF、TNF-α或 IL-6 水平与 PDR 之间存在关联。炎症生物标志物在 PDR 中的作用需要在进一步的研究中加以解决。
