Division of Neonatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA.
Neonatology. 2020;117(5):577-583. doi: 10.1159/000509038. Epub 2020 Aug 14.
Lipid peroxidation products are present following oxidation of polyunsaturated fatty acids in the eye, brain, and various cell membranes. Elevated levels of lipid peroxidation products and increased intermittent hypoxemia (IH) events have been associated with adverse outcomes in extremely preterm infants. The moderate preterm newborn has a still-developing oxidant defense system and immature respiratory control, but little is known about lipid peroxidation levels and IH in this larger and more common preterm population.
To determine the association between oxidative stress and IH in moderate preterm infants.
Oxygen saturation was continuously monitored in 51 moderate preterm infants (i.e., 31 + 0/7 to 33 + 6/7 weeks' gestation). Urine samples were collected at the end of the first and second weeks of life. Samples were analyzed for total lipid peroxidation products (neurofurans, isofurans, neuroprostanes, isoprostanes, and di-homo-isofurans).
At week 1, there was a correlation between increased IH frequency and neurofurans (p < 0.04) and di-homo-isofurans (p < 0.003). At week 2, there was no correlation between IH and lipid peroxidation markers. Ele-vations in neurofurans, isofurans, neuroprostanes, and di-homo-isofurans in the first and/or second week of life were associated with a longer stay in hospital.
Elevations in lipid peroxidation biomarkers in moderate preterm infants during their first weeks of life are associated with a higher frequency of IH and prolonged hospitalization.
多不饱和脂肪酸在眼、脑和各种细胞膜中氧化后，会产生脂质过氧化产物。脂质过氧化产物水平升高和间歇性低氧血症（IH）事件增加与极早产儿的不良结局有关。适度早产儿的氧化防御系统仍在发育，呼吸控制不成熟，但对于这个更大且更常见的早产儿群体，其脂质过氧化水平和 IH 知之甚少。
确定氧化应激与中度早产儿 IH 之间的关系。
对 51 名中度早产儿（即 31+0/7 至 33+6/7 周妊娠）连续监测氧饱和度。在生命的第一和第二周结束时收集尿液样本。分析样本中的总脂质过氧化产物（神经呋喃、异呋喃、神经前列腺素、异前列腺素和二同型异呋喃）。
第 1 周，IH 频率增加与神经呋喃（p<0.04）和二同型异呋喃（p<0.003）呈正相关。第 2 周，IH 与脂质过氧化标志物之间无相关性。在生命的第一和/或第二周神经呋喃、异呋喃、神经前列腺素和二同型异呋喃升高与住院时间延长有关。
中度早产儿在生命的最初几周内脂质过氧化生物标志物升高与 IH 频率增加和住院时间延长有关。
