Guduru Abhilash, Rasheed Mohammed Abdul, Goud Abhilash, Vupparaboina Kiran Kumar, Agrawal Rupesh, Lupidi Marco
University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Nepal J Ophthalmol. 2020 Jan;12(23):48-55. doi: 10.3126/nepjoph.v12i1.25188.
To characterize the peripapillary choroidal vasculature in healthy individuals using the choroidal vascular index (CVI), a previously established more robust tool of measurement of choroidal vascularity than choroidal thickness.
The peripapillary choroid in healthy individuals was analyzed using optical coherence tomography. OCT B-scan were analyzed using automated binarization, a previously established technique. This separates the choroidal layer into the stromal and vascular areas. Choroidal vascular index (CVI), the vascular area/total area, was computed for each image over the macula and the peripapillary area of the optic disc. Regression analysis and generalized estimating equation (GEE) were used to analyze various demographics, and CVI in the macula and each quadrant of the optic disc.
Fifty eight eyes of 29 healthy individuals were included. Mean age was 42±17 years. Average CVI at the macula was 0.583. Average peripapillary CVI was 0.643 (nasal), 0.598 (temporal), 0.621 (superior) and 0.623 (inferior). Regression analysis of variables demonstrated there was no significant relationship between the demographic variables and macular CVI. However, the analysis demonstrated age and CVI of the peripapillary area were significantly correlated. Further stratification revealed significantly higher CVI in the optic disc in subjects over 45.
Peripapillary CVI in all quadrants is higher than macular CVI in all age groups. CVI significantly increases after the age of 45 in the peripapillary area but not macular area. This suggests that stromal area decline is greater than the decline of the luminal area in the choroid at the peripapillary area as age increases.
使用脉络膜血管指数（CVI）来描述健康个体的视乳头周围脉络膜血管系统，CVI是一种先前建立的比脉络膜厚度更强大的脉络膜血管测量工具。
使用光学相干断层扫描分析健康个体的视乳头周围脉络膜。使用自动二值化分析OCT B扫描，这是一种先前建立的技术。这将脉络膜层分为基质和血管区域。计算黄斑和视盘视乳头周围区域每个图像的脉络膜血管指数（CVI），即血管面积/总面积。使用回归分析和广义估计方程（GEE）分析各种人口统计学数据以及黄斑和视盘每个象限的CVI。
纳入29名健康个体的58只眼睛。平均年龄为42±17岁。黄斑处的平均CVI为0.583。视乳头周围平均CVI为：鼻侧0.643、颞侧0.598、上方0.621、下方0.623。变量的回归分析表明，人口统计学变量与黄斑CVI之间无显著关系。然而，分析表明视乳头周围区域的年龄与CVI显著相关。进一步分层显示，45岁以上受试者视盘中的CVI显著更高。
所有年龄组中，视乳头周围所有象限的CVI均高于黄斑CVI。45岁以后，视乳头周围区域的CVI显著增加，但黄斑区域没有。这表明随着年龄的增长，视乳头周围区域脉络膜的基质面积下降大于管腔面积的下降。
