Guduru Abhilash, Abdul Rasheed Mohammed, Goud Abhilash, Ashik Mohamed, Kumar Vupparaboina Kiran, Chhablani Jay, Badakere Akshay, Kekunnaya Ramesh, Patil-Chhablani Preeti
Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Smt. Kanuri Santhamma Centre for Vitreo Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India.
Neuroophthalmology. 2019 Feb 1;43(5):305-309. doi: 10.1080/01658107.2019.1566384. eCollection 2019 Nov.
This study evaluates the peripapillary choroidal vascularity in eyes with non-arteritic anterior ischaemic optic neuropathy (NAION) and compares it with the vascularity of healthy fellow eyes and age-matched subjects. The peripapillary choroidal vascularity index (CVI), a new tool of measurement, was calculated using horizontal swept-source optical coherence tomography scans. CVI was calculated using a previously validated automated algorithm. CVI in NAION and fellow eyes of NAION patients were compared with age-matched eyes of healthy individuals using Kruskal-Wallis test. A total of 20 eyes of 20 patients with acute unilateral NAION with healthy fellow eyes (20 eyes) and 40 eyes of 40 healthy patients were included in the study. The average age of patients with NAION was 56 ± 8 and 55 ± 7 years in age-matched healthy controls. NAION eyes had a significantly lower CVI than age-matched controls in both nasal and temporal areas. NAION nasal CVI was 0.47 ± 0.47 compared to 0.62 ± 0.04 in controls ( < 0.001). NAION temporal CVI was 0.45 ± 0.48 compared to 0.58 ± 0.04 in controls ( < 0.001). Temporal CVI was 0.45 ± 0.48 in NAION eyes and was significantly lower than counterpart healthy fellow eyes 0.48 ± 0.02 ( = 0.007). In conclusion, NAION eyes have significantly reduced vascularity in the peripapillary area. CVI is lower in the nasal and temporal of the optic disc compared to healthy individuals. This may suggest those with smaller CVI are more prone to ischaemia from reduced vascularity resulting in NAION.
本研究评估非动脉炎性前部缺血性视神经病变（NAION）患者眼部视乳头周围脉络膜血管情况，并将其与健侧眼及年龄匹配的对照者的血管情况进行比较。使用水平扫频光学相干断层扫描，计算视乳头周围脉络膜血管指数（CVI）这一新型测量工具。CVI采用先前验证的自动算法计算得出。采用Kruskal-Wallis检验，将NAION患者及其健侧眼的CVI与年龄匹配的健康个体的眼睛进行比较。本研究共纳入20例急性单侧NAION患者的20只患眼（健侧眼20只）以及40例健康患者的40只眼睛。NAION患者的平均年龄为56±8岁，年龄匹配的健康对照者为55±7岁。NAION患眼在鼻侧和颞侧区域的CVI均显著低于年龄匹配的对照者。NAION鼻侧CVI为0.47±0.47，而对照者为0.62±0.04（P<0.001）。NAION颞侧CVI为0.45±0.48，对照者为0.58±0.04（P<0.001）。NAION患眼的颞侧CVI为0.45±0.48，显著低于对侧健侧眼的0.48±0.02（P = 0.007）。总之，NAION患眼视乳头周围区域的血管明显减少。与健康个体相比，视盘鼻侧和颞侧的CVI较低。这可能表明CVI较小者更容易因血管减少导致缺血，进而引发NAION。
