Khaliq Taqdees, Khan Asfandyar, Malik Iftikhar Ahmed
Department of Rheumatology, Federal Government Polyclinic, Islamabad, Pakistan.
Department of Orthopaedic Surgery, King Edward Medical University, Lahore, Pakistan.
J Pak Med Assoc. 2020 Jul;70(7):1143-1149. doi: 10.5455/JPMA.289952.
To examine the clinical and laboratory features and to measure treatment outcomes after using different disease-modifying antirheumatic drugs in patients of rheumatoid arthritis.
The observational study was conducted at the Rheumatology Unit of Federal Government Polyclinic Hospital, Islamabad, Pakistan,from March 15, 2014,to September 14, 2015, and comprised rheumatoid arthritis patients of either gender diagnosed according to the American College of Rheumatology criteria.Disease activity score-28 and a thorough examination of the joints were employed to assess disease activity. Data was analysed using SPSS 20.
Of the 63 patients, 18(28.6%) were males and 45(71.4%) were females. The overall mean age was 43.09±13.03 years and mean duration of disease was 5.05±5.58 years. Seropositive disease was noted in 58(92.1%) patients and they had a higher level of erythrocyte sedimentation rate. Mean disease activity score-28 score at baseline was 5.52±0.99. At the end of 6 months, 44(69.8%) patients were in remission, 18(28.6%) had low disease activity and 1(1.6%) had moderate disease activity. The mean DAS score reduced to 3.11 0.77 at 6 months. Overall, 28(44.4%) patients had joint deformities.
Females had a higher incidence of rheumatoid arthritis compared to males, and, overall, there was a high prevalence of joint deformities.
研究类风湿关节炎患者使用不同抗风湿药物后的临床和实验室特征，并评估治疗效果。
该观察性研究于2014年3月15日至2015年9月14日在巴基斯坦伊斯兰堡联邦政府综合医院的风湿病科进行，纳入符合美国风湿病学会标准诊断的类风湿关节炎患者，男女不限。采用疾病活动度评分-28和对关节进行全面检查来评估疾病活动度。使用SPSS 20对数据进行分析。
63例患者中，男性18例（28.6%），女性45例（71.4%）。总体平均年龄为43.09±13.03岁，平均病程为5.05±5.58年。58例（92.1%）患者血清学阳性，且红细胞沉降率水平较高。基线时疾病活动度评分-28的平均得分为5.52±0.99。6个月末，44例（69.8%）患者病情缓解，18例（28.6%）疾病活动度低，1例（1.6%）疾病活动度中等。6个月时DAS评分平均降至3.11±0.77。总体而言，28例（44.4%）患者有关节畸形。
女性类风湿关节炎的发病率高于男性，总体上关节畸形的患病率较高。
