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1

Computational Drug Repurposing Approach to Identify Potential Fatty Acid-Binding Protein-4 Inhibitors to Develop Novel Antiobesity Therapy.计算药物再利用方法鉴定潜在的脂肪酸结合蛋白-4 抑制剂以开发新型抗肥胖疗法。

Assay Drug Dev Technol. 2020 Oct;18(7):318-327. doi: 10.1089/adt.2020.976. Epub 2020 Aug 14.

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The mAb against adipocyte fatty acid-binding protein 2E4 attenuates the inflammation in the mouse model of high-fat diet-induced obesity via toll-like receptor 4 pathway.抗脂肪细胞脂肪酸结合蛋白2E4单克隆抗体通过Toll样受体4途径减轻高脂饮食诱导肥胖小鼠模型中的炎症。

Mol Cell Endocrinol. 2015 Mar 5;403:1-9. doi: 10.1016/j.mce.2014.12.017. Epub 2015 Jan 14.

3

Application of target repositioning and in silico screening to exploit fatty acid binding proteins (FABPs) from Echinococcus multilocularis as possible drug targets.应用靶标重定位和计算机筛选技术，从多房棘球绦虫脂肪酸结合蛋白（FABPs）中寻找可能的药物靶点。

J Comput Aided Mol Des. 2020 Dec;34(12):1275-1288. doi: 10.1007/s10822-020-00352-8. Epub 2020 Oct 17.

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A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors.计算机辅助发现新型潜在的抗肥胖化合物作为选择性碳酸酐酶 VA 抑制剂。

Eur J Med Chem. 2019 Nov 1;181:111565. doi: 10.1016/j.ejmech.2019.111565. Epub 2019 Jul 27.

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From Homology Modeling to the Hit Identification and Drug Repurposing: A Structure-Based Approach in the Discovery of Novel Potential Anti-Obesity Compounds.从同源建模到命中化合物识别与药物再利用：基于结构的方法发现新型潜在抗肥胖化合物

Methods Mol Biol. 2021;2266:263-277. doi: 10.1007/978-1-0716-1209-5_15.

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Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.脂肪细胞脂肪酸结合蛋白 4（FABP4）抑制剂。全面系统评价。

Eur J Med Chem. 2017 Sep 29;138:854-873. doi: 10.1016/j.ejmech.2017.07.022. Epub 2017 Jul 15.

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Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening.使用分子对接筛选发现被 FDA 批准的药物作为脂肪酸结合蛋白 4 的抑制剂。

J Chem Inf Model. 2014 Nov 24;54(11):3046-50. doi: 10.1021/ci500503b. Epub 2014 Nov 4.

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Fermented Platycodon grandiflorum Extract Inhibits Lipid Accumulation in 3T3-L1 Adipocytes and High-Fat Diet-Induced Obese Mice.发酵桔梗提取物抑制3T3-L1脂肪细胞和高脂饮食诱导的肥胖小鼠中的脂质积累。

J Med Food. 2016 Nov;19(11):1004-1014. doi: 10.1089/jmf.2016.3805. Epub 2016 Oct 28.

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Small molecule inhibitors of human adipocyte fatty acid binding protein (FABP4).人脂肪细胞脂肪酸结合蛋白（FABP4）的小分子抑制剂

Med Chem. 2014 Jun;10(4):339-47. doi: 10.2174/15734064113096660045.

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SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins.SAR 研究表明，曲昔派特单酯类化合物是一类新型的靶向脂肪酸结合蛋白的抗伤害感受药物。

Eur J Med Chem. 2018 Jun 25;154:233-252. doi: 10.1016/j.ejmech.2018.04.050. Epub 2018 May 26.

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计算药物再利用方法鉴定潜在的脂肪酸结合蛋白-4 抑制剂以开发新型抗肥胖疗法。

Computational Drug Repurposing Approach to Identify Potential Fatty Acid-Binding Protein-4 Inhibitors to Develop Novel Antiobesity Therapy.

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