自噬在神经元发育和可塑性中的作用。
Autophagy in Neuronal Development and Plasticity.
机构信息
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
出版信息
Trends Neurosci. 2020 Oct;43(10):767-779. doi: 10.1016/j.tins.2020.07.003. Epub 2020 Aug 13.
Autophagy is a highly conserved intracellular clearance pathway in which cytoplasmic contents are trafficked to the lysosome for degradation. Within neurons, it helps to remove damaged organelles and misfolded or aggregated proteins and has therefore been the subject of intense research in relation to neurodegenerative disease. However, far less is understood about the role of autophagy in other aspects of neuronal physiology. Here we review the literature on the role of autophagy in maintaining neuronal stem cells and in neuronal plasticity in adult life and we discuss how these contribute to structural and functional deficits observed in a range of human disorders.
自噬是一种高度保守的细胞内清除途径，其中细胞质内容物被运输到溶酶体进行降解。在神经元中，它有助于清除受损的细胞器和错误折叠或聚集的蛋白质，因此一直是神经退行性疾病相关研究的热点。然而，人们对自噬在神经元生理学其他方面的作用知之甚少。在这里，我们回顾了自噬在维持神经元干细胞和成年期神经元可塑性中的作用的文献，并讨论了这些作用如何导致一系列人类疾病中观察到的结构和功能缺陷。
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