Walsh C, Smith C E, Ryan B, Polomeno R C, Bevan J C
Department of Anaesthesia, Montreal Children's Hospital, Quebec.
Can J Anaesth. 1988 Jan;35(1):31-5. doi: 10.1007/BF03010541.
The study was designed to compare the frequency and severity of postoperative vomiting in paediatric out-patients receiving controlled ventilation (IPPV) or breathing spontaneously (SV) during anaesthesia for strabismus repair. One hundred and twenty unpremedicated children (ages 2-12 years) were studied in a randomized fashion. After intravenous induction of anaesthesia and tracheal intubation, patients breathed halothane 1-1.5 per cent inspired and N2O 66 per cent in O2 spontaneously (n = 60), or received IPPV, halothane 0.5-1 per cent, N2O 66 per cent, and pancuronium 0.05 mg.kg-1, which was reversed with neostigmine and atropine (n = 60). The incidence of vomiting with SV was 50 per cent (95 per cent confidence limits: 34.5-65.5 per cent) compared with 40 per cent (24.5-55.5 per cent) with IPPV (p greater than 0.25). Patients in the SV group experiencing emesis had longer operations than those not vomiting (mean +/- SEM = 1.5 +/- 0.1 vs 1.2 +/- 0.1 hours, p less than 0.005). This was not the case with IPPV. There was no correlation between age, sex, duration of surgery, or number of extraocular muscles repaired, and frequency or severity of vomiting or time to discharge. No significant advantage was afforded by IPPV over SV in the present study.
本研究旨在比较小儿斜视修复手术麻醉期间接受控制通气(间歇正压通气,IPPV)或自主呼吸(自主通气,SV)的门诊患儿术后呕吐的频率和严重程度。120例未用术前药的儿童(年龄2至12岁)被随机纳入研究。静脉诱导麻醉和气管插管后,患者自主呼吸含1% - 1.5%氟烷和66%氧化亚氮的氧气(n = 60),或接受IPPV,吸入0.5% - 1%氟烷、66%氧化亚氮和0.05mg/kg泮库溴铵,并用新斯的明和阿托品拮抗(n = 60)。自主通气组呕吐发生率为50%(95%置信区间:34.5% - 65.5%),而IPPV组为40%(24.5% - 55.5%)(p>0.25)。自主通气组发生呕吐的患者手术时间比未呕吐者长(均值±标准误=1.5±0.1 vs 1.2±0.1小时,p<0.005)。IPPV组情况并非如此。年龄、性别、手术时间或修复的眼外肌数量与呕吐频率或严重程度以及出院时间之间无相关性。在本研究中,IPPV相比自主通气并无显著优势。