Rita L, Goodarzi M, Seleny F
Can Anaesth Soc J. 1981 May;28(3):259-62. doi: 10.1007/BF03005511.
This double-blind study assessed the effect of low dose droperidol (0.005 mg x kg-1) on the incidence of postoperative vomiting in 200 children in ASA classification I and II, ranging from one to 15 years of age. The results showed that the dose of droperidol used in this study was very effective in reducing vomiting in children 11 to 15 years of age. The duration of stay in the post-anaesthetic care unit was not prolonged and no extrapyramidal symptoms related to the drug were observed. In our opinion the administration of droperidol 0.005 mg x kg-1 before the end of the operation will reduce the possibility of vomiting within 24 hours of operation in children in 11-15 year age group who are expected to have a high incidence of postoperative vomiting.
这项双盲研究评估了低剂量氟哌利多(0.005毫克/千克)对200名年龄在1至15岁、ASA分级为I级和II级儿童术后呕吐发生率的影响。结果表明,本研究中使用的氟哌利多剂量在减少11至15岁儿童呕吐方面非常有效。在麻醉后护理单元的停留时间没有延长,也未观察到与该药物相关的锥体外系症状。我们认为,对于预计术后呕吐发生率较高的11至15岁儿童,在手术结束前给予0.005毫克/千克的氟哌利多将降低术后24小时内呕吐的可能性。