Moreira Rodrigo C, Mendonca-Filho Hugo T, Farias Ayla M, Sznejder Henry, Lang Eddy, Wilson Margaret M
Department of Clinical Research, United Health Group, Rio de Janeiro, Brazil.
Clinical Intelligence, Amil Assistencia Médica Internacional, Rio de Janeiro, Brazil.
Open Access Emerg Med. 2020 Jul 30;12:181-191. doi: 10.2147/OAEM.S256220. eCollection 2020.
Patients with community-acquired pneumonia (CAP) at low risk of death by CURB-65 scoring system are usually unnecessarily treated as inpatients generating additional economic and clinical burden. We aimed to implement an evidence-based clinical pathway to reduce hospital admissions of low-risk CAP and investigate factors related to mortality and readmissions within 30 days.
From November 2015 to August 2017, a clinical pathway was implemented at 20 hospitals. We included patients aged >18 years, with a diagnosis of CAP by the attendant physician. The main outcome was the monthly proportion of low-risk CURB-65 admission after the implementation of the clinical pathway. Logistic regression models were performed to assess variables associated with mortality and readmission in the admitted population within 30 days.
We included 10,909 participants with suspected CAP. The proportion of low-risk CAP admitted decreased from 22.1% to 12.8% in the period. Among participants with low risk, there has been no perceptible increase in deaths (0.80%) or readmissions (6.92%). Regression analysis identified that CURB-65 variables, presence of pleural effusion (OR= 1.74; 95%CI=1.08-2.8; p=0.02) and leucopenia (OR= 2.47; 95%CI=1.11-5.48; p=0.02) were independently associated with 30-day mortality, whereas a prolonged hospital stay (OR= 2.09; 95%CI=1.14-3.83; p=0.01) was associated with 30-day readmission in the low-risk population.
The implementations of a clinical pathway diminished the proportion of low-risk CAP admissions with no apparent increase in clinical outcomes within 30 days. Nonetheless, additional factors influence the clinical decision about the site of care management in low-risk CAP.
通过CURB-65评分系统判定为死亡低风险的社区获得性肺炎(CAP)患者通常被不必要地作为住院患者治疗,从而产生额外的经济和临床负担。我们旨在实施基于证据的临床路径,以减少低风险CAP患者的住院率,并调查与30天内死亡率和再入院相关的因素。
2015年11月至2017年8月期间,20家医院实施了临床路径。纳入年龄大于18岁、经主治医生诊断为CAP的患者。主要结局是临床路径实施后每月低风险CURB-65住院患者的比例。采用逻辑回归模型评估与30天内入院人群的死亡率和再入院相关的变量。
我们纳入了10909例疑似CAP的参与者。在此期间,低风险CAP患者的入院比例从22.1%降至12.8%。在低风险参与者中,死亡(0.80%)或再入院(6.92%)没有明显增加。回归分析确定,CURB-65变量、胸腔积液的存在(比值比=1.74;95%置信区间=1.08-2.8;p=0.02)和白细胞减少(比值比=2.47;95%置信区间=1.11-5.48;p=0.02)与30天死亡率独立相关,而住院时间延长(比值比=2.09;95%置信区间=1.14-3.83;p=0.01)与低风险人群的30天再入院相关。
临床路径的实施降低了低风险CAP患者的入院比例,且30天内临床结局无明显增加。尽管如此,其他因素会影响低风险CAP患者护理管理地点的临床决策。