Taherian Mahdi, Mahin Samadi Pariya, Rastegar Hossein, Faramarzi Mohammad Ali, Rostami-Nejad Mohammad, Yazdi Mohammad Hossein, Rezaei-Tavirani Mostafa, Yazdi Zeinab
Food and Drug Laboratory Research Center, Iran Food and Drug Organization (FDO), Ministry of Health and Medical Education (MOH), Tehran, Iran.
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2019 Fall;18(Suppl1):31-50. doi: 10.22037/ijpr.2020.112232.13620.
Probiotics are viable and useful microorganisms, which are beneficial factors for human and animal health by altering their microbial flora. Most of the probiotics belong to a large group of bacteria in the human gastrointestinal tract. There are several clinical shreds of evidence that show anti-carcinogenic effects of probiotics through altering digestive enzymes, inhibition of carcinogenic agents, and modulating the immune responses in experimental animals. Many studies have been performed to evaluate the potential effectiveness of probiotics in treating or preventing neurological diseases such as MS and novel treatment modality for T1D. The purpose of this study is to have an overview on probiotic microorganisms and to review the previous researches on the effects of probiotics on health through currently available literatures. The study was performed using following keywords; Probiotics, Cancer, Immune system, Multiple Sclerosis (MS) and Diabetes mellitus. PubMed/Medline, Clinicaltrials.gov, Ovid, Google Scholar, and Reaxcys databases used to find the full text of related articles. According to the current available data on probiotics and related health-promoting benefits, it seems that, consumption of probiotics can lead to the prevention and reduction the risk of cancer, diabetes, and multiple sclerosis. Although for the better and more decisive conclusion, there is a need to larger sample size clinical studies with more focus on the safety of these biological agents and their possible beneficial effects on different population.
益生菌是活的且有益的微生物，通过改变人类和动物的微生物菌群，对其健康具有有益作用。大多数益生菌属于人类胃肠道中的一大类细菌。有若干临床证据表明，益生菌通过改变消化酶、抑制致癌物质以及调节实验动物的免疫反应，具有抗癌作用。已经开展了许多研究来评估益生菌在治疗或预防诸如多发性硬化症等神经疾病以及作为1型糖尿病新治疗方式方面的潜在效果。本研究的目的是概述益生菌微生物，并通过现有文献回顾此前关于益生菌对健康影响的研究。该研究使用了以下关键词进行：益生菌、癌症、免疫系统、多发性硬化症（MS）和糖尿病。使用PubMed/Medline、Clinicaltrials.gov、Ovid、谷歌学术和Reaxcys数据库查找相关文章的全文。根据目前关于益生菌及其相关健康促进益处的可用数据，食用益生菌似乎可以预防和降低患癌症、糖尿病和多发性硬化症的风险。尽管为了得出更好、更具决定性的结论，需要开展更大样本量的临床研究，更加关注这些生物制剂的安全性及其对不同人群可能产生的有益影响。
