Jonasson Stina B, Rantakokko Merja, Franzén Erika, Iwarsson Susanne, Nilsson Maria H
Memory Clinic, Skåne University Hospital, Malmö, Sweden.
School of Health and Social Studies, JAMK University of Applied Sciences, Jyväskylä, Finland.
Parkinsons Dis. 2020 Jul 29;2020:1561037. doi: 10.1155/2020/1561037. eCollection 2020.
People with Parkinson's disease (PD) have lower life satisfaction (LS) than healthy peers. No study has yet identified predictors of LS in people with PD. Such information would be valuable for health care and future interventions that aim to maintain or increase LS.
To examine how LS evolved in people with PD over a 3-year period, as well as to identify predictive factors of LS.
We used data from baseline assessments and a 3-year follow-up of 163 people with PD (baseline, mean age 68 years; median PD duration 8 years, 35% women). LS was assessed with item 1 of the Life Satisfaction Questionnaire (LiSat-11). Dichotomized LS data from the 3-year follow-up were used as the dependent variable in multivariable logistic regression analyses. In the first step, independent variables included baseline information on sex, education, general self-efficacy, motor symptoms, perceived walking difficulties, fall-related activity avoidance, and difficulties with/need help in activities of daily living. At the second step, depressive symptoms were added as an independent variable.
The proportion of those who reported being satisfied with their lives reduced from 63.2% at baseline to 49.7% 3 years later (=0.003). When depressive symptoms were not included in the analysis, general self-efficacy (odds ratio, OR = 1.081; 95% CI = 1.019-1.147) and perceived walking difficulties (OR = 0.962; 95% CI = 0.929-0.997) were significant ( < 0.05) predictors of LS 3 years later. With depressive symptoms included, the influence of walking difficulties diminished, and depressive symptoms (OR = 0.730; 95% CI = 0.607-0.877) and general self-efficacy (OR = 1.074; 95% CI = 1.010-1.142) were the only significant predictors of LS 3 years later.
LS is reduced over a 3-year period. The study suggests that perceived walking difficulties, general self-efficacy, and depressive symptoms are important predictors of LS in people with PD.
帕金森病（PD）患者的生活满意度（LS）低于健康同龄人。尚无研究确定PD患者生活满意度的预测因素。此类信息对于旨在维持或提高生活满意度的医疗保健和未来干预措施具有重要价值。
研究PD患者在3年期间生活满意度的变化情况，并确定生活满意度的预测因素。
我们使用了163例PD患者基线评估和3年随访的数据（基线时，平均年龄68岁；PD病程中位数8年，女性占35%）。生活满意度采用生活满意度问卷（LiSat-11）的第1项进行评估。3年随访中二分法的生活满意度数据用作多变量逻辑回归分析的因变量。第一步，自变量包括性别、教育程度、一般自我效能感、运动症状、感知到的行走困难、避免与跌倒相关的活动以及日常生活活动中的困难/需要帮助等基线信息。第二步，将抑郁症状作为自变量纳入。
报告对生活满意的患者比例从基线时的63.2%降至3年后的49.7%（ =0.003）。在分析中未纳入抑郁症状时，一般自我效能感（优势比，OR = 1.081；95%置信区间 = 1.019 - 1.147）和感知到的行走困难（OR = 0.962；95%置信区间 = 0.929 - 0.997）是3年后生活满意度的显著（ < 0.05）预测因素。纳入抑郁症状后，行走困难的影响减弱，抑郁症状（OR = 0.730；95%置信区间 = 0.607 - 0.877）和一般自我效能感（OR = 1.074；95%置信区间 = 1.010 - 1.142）是3年后生活满意度的仅有的显著预测因素。
生活满意度在3年期间有所降低。该研究表明，感知到的行走困难、一般自我效能感和抑郁症状是PD患者生活满意度的重要预测因素。
